About: Spondweni virus causes fetal harm in Ifnar1(-/-) mice and is transmitted by Aedes aegypti mosquitoes

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Spondweni virus causes fetal harm in Ifnar1(-/-) mice and is transmitted by Aedes aegypti mosquitoes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spondweni virus causes fetal harm in Ifnar1(-/-) mice and is transmitted by Aedes aegypti mosquitoes
Creator	Aliota, Matthew Friedrich, Thomas O'connor, David O'connor, Shelby Jaeger, Anna Aliota, T Friedrich, M Fritsch, Michael Jaeger, A Moriarty, A Moriarty, Ryan O'connor, S Rybarczyk, R Rybarczyk, Sierra Seelig, Davis Seeling, Davis Weiler, Andrea
Source	Elsevier; Medline; PMC
abstract	Spondweni virus (SPONV) is the most closely related known flavivirus to Zika virus (ZIKV). Its pathogenic potential and vector specificity have not been well defined. SPONV has been found predominantly in Africa, but was recently detected in a pool of Culex quinquefasciatus mosquitoes in Haiti. Here we show that SPONV can cause significant fetal harm, including demise, comparable to ZIKV, in a mouse model of vertical transmission. Following maternal inoculation, we detected infectious SPONV in placentas and fetuses, along with significant fetal and placental histopathology, together suggesting vertical transmission. To test vector competence, we exposed Aedes aegypti and Culex quinquefasciatus mosquitoes to SPONV-infected bloodmeals. Aedes aegypti could efficiently transmit SPONV, whereas Culex quinquefasciatus could not. Our results suggest that SPONV has the same features that made ZIKV a public health risk.
has issue date	2020-05-24(xsd:dateTime)
bibo:doi	10.1016/j.virol.2020.05.005
bibo:pmid	32560903
has license	no-cc
sha1sum (hex)	7c7f85c35bf5634b243e8492eae0214976bcf2b8
schema:url	https://doi.org/10.1016/j.virol.2020.05.005
resource representing a document's title	Spondweni virus causes fetal harm in Ifnar1(-/-) mice and is transmitted by Aedes aegypti mosquitoes
has PubMed Central identifier	PMC7246013
has PubMed identifier	32560903
schema:publication	Virology
resource representing a document's body	covid:7c7f85c35bf5634b243e8492eae0214976bcf2b8#body_text
is schema:about of	named entity 'mouse' named entity 'Culex' named entity 'model' named entity 'author' named entity 'Ifnar1' named entity 'Ifnar1' named entity 'COMPETENCE' named entity 'PLACENTAS' named entity 'INFECTIOUS' named entity 'POTENTIAL' named entity 'TRANSMIT' named entity 'BUT' named entity 'vertical transmission' named entity 'Our' named entity 'blood flow' named entity 'ZIKV' named entity 'ZIKV' named entity 'ZIKV' named entity 'ZIKV' named entity 'inoculation' named entity 'Student's t-test' named entity 'vascular systems' named entity 'growth retardation' named entity 'conceptus' named entity 'placenta' named entity 'placenta' named entity 'serum' named entity 'fetal' named entity 'developing fetus' named entity 'inflammation' named entity 'inoculation' named entity 'fetal resorption' named entity 'PBS' named entity 'fetal' named entity 'fetal tissue' named entity 'correction for multiple comparisons' named entity 'mice' named entity 'ZIKV' named entity 'challenge groups' named entity 'treatment groups' named entity 'clinical cases' named entity 'lung' named entity 'infection' named entity 'ZIKV' named entity 'ZIKV' named entity 'Haiti' named entity 'virus' named entity 'fetal' named entity 'serological' named entity 'flaviviruses' named entity 'uterine' named entity 'phenotype' named entity 'ZIKV' named entity 'fetus' named entity 'infection' named entity 'infection' named entity 'fetal' named entity 'Virus' named entity 'necrosis' named entity 'pregnancy' named entity 'Infection' named entity 'mAb' named entity 'hematoxylin and eosin' named entity 'Haiti' named entity 'Culex quinquefasciatus'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software