About: Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using label-free quantitative proteomics

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About: Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using label-free quantitative proteomics Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using label-free quantitative proteomics
Creator	Shen, Chen Xu, Fang Jiao, Weiwei Li, Jieqiong Qi, Hui Shen, Adong Sun, Lin Xiao, Jing
source	Medline; PMC
abstract	Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is an infectious disease found worldwide. Children infected with MTB are more likely to progress to active TB (ATB); however, the molecular mechanism behind this process has long been a mystery. We employed the label-free quantitative proteomic technology to identify and characterize differences in plasma proteins between ATB and latent TB infection (LTBI) in children. To detect differences that are indicative of MTB infection, we first selected proteins whose expressions were markedly different between the ATB and LTBI groups and the control groups (inflammatory disease control (IDC) and healthy control (HC) groups). A total of 521 proteins differed (> 1.5-fold or < 0.6-fold) in the LTBI group, and 318 proteins in the ATB group when compared with the control groups. Of these, 49 overlapping proteins were differentially expressed between LTBI and ATB. Gene Ontology (GO) analysis revealed most proteins had a cellular and organelle distribution. The MTB infection status was mainly related to differences in binding, cellular and metabolic processes. XRCC4, PCF11, SEMA4A and ATP11A were selected and further verified by qPCR and western blot. At the mRNA level, the expression of XRCC4, PCF11and SEMA4A presented an increased trend in ATB group compare with LTBI. At the protein level, the expression of all these proteins by western blot in ATB/LTBI was consistent with the trends from proteomic detection. Our results provide important data for future mechanism studies and biomarker selection for MTB infection in children.
has issue date	2017-09-23(xsd:dateTime)
bibo:doi	10.18632/oncotarget.21179
bibo:pmid	29262562
has license	cc-by
sha1sum (hex)	7da4fcd53b89c33706e7e63f8b2f527f27f07ef8
schema:url	https://doi.org/10.18632/oncotarget.21179
resource representing a document's title	Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using label-free quantitative proteomics
has PubMed Central identifier	PMC5732728
has PubMed identifier	29262562
schema:publication	Oncotarget
resource representing a document's body	covid:7da4fcd53b89c33706e7e63f8b2f527f27f07ef8#body_text
is schema:about of	named entity 'organelle' named entity 'MTB' named entity 'proteins' named entity 'expressions' named entity 'total' named entity 'indicative' named entity 'label-free' named entity 'ATB' named entity 'group' named entity 'Children' named entity 'long' named entity 'infection' named entity 'CHILDREN' covid:arg/7da4fcd53b89c33706e7e63f8b2f527f27f07ef8 named entity 'MECHANISM' named entity 'COMPARED' named entity 'INFECTION' named entity 'TOTAL' named entity 'INFECTION STATUS' named entity 'LIKELY' named entity 'EXPRESSIONS' named entity 'DIFFERENT' named entity 'EXPRESSION' named entity 'DATA' named entity 'PROVIDE' named entity 'DISEASE CONTROL' named entity 'TECHNOLOGY' named entity 'PRESENTED' named entity 'RESULTS' named entity 'PLASMA PROTEINS' named entity 'ATB' named entity 'RELATED' named entity 'MTB' named entity 'QPCR' named entity 'PROGRESS' named entity 'ATP11A' named entity 'BIOMARKER' named entity 'TO DETECT' named entity 'MRNA' named entity '0.6' named entity 'SEMA4A' named entity 'XRCC4' named entity 'HEALTHY CONTROL' named entity 'WORLDWIDE' named entity 'MARKEDLY' named entity 'MOLECULAR MECHANISM' named entity 'FOUND' named entity 'CONSISTENT WITH' named entity 'WESTERN BLOT' named entity 'TO IDENTIFY' named entity 'ANALYSIS' named entity 'REVEALED' named entity 'INFECTED' named entity 'PROCESS' named entity 'CHILDREN' named entity 'LATENT' named entity 'INFECTIOUS DISEASE' named entity 'LABEL-FREE QUANTITATIVE PROTEOMICS' named entity 'MYCOBACTERIUM TUBERCULOSIS INFECTION' named entity 'METABOLIC PROCESSES' named entity 'IMPORTANT' named entity 'QUANTITATIVE' named entity '1.5' named entity 'LEVEL' named entity 'EMPLOYED' named entity 'GENE ONTOLOGY' named entity 'PROTEOMIC' named entity 'DIFFERENT' named entity 'USING' named entity 'INFECTION STATUS' named entity 'ORGANELLE DISTRIBUTION' named entity 'CHARACTERIZATION' named entity 'PLASMA PROTEINS' named entity 'SELECTION'

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