About: Assessment of airflow limitation, airway inflammation, and symptoms during virus-induced wheezing episodes in 4- to 6-year-old children

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About: Assessment of airflow limitation, airway inflammation, and symptoms during virus-induced wheezing episodes in 4- to 6-year-old children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Assessment of airflow limitation, airway inflammation, and symptoms during virus-induced wheezing episodes in 4- to 6-year-old children
Creator	Xepapadaki, Paraskevi Makrinioti, Heidi Papadopoulos, Nikolaos Konstantinou, George Greece, Athens, Kouloufakou-Gratsia, Kalliopi Manousakis, Emmanuel Saxoni-Papageorgiou, Photini
Source	Elsevier; Medline; PMC
abstract	Background It is disputed whether recurrent episodes of wheeze in preschool-aged children comprise a distinct asthma phenotype. Objective We sought to prospectively assess airflow limitation and airway inflammation in children 4 to 6 years old with episodic virus-induced wheeze. Methods Ninety-three children 4 to 6 years old with a history of mild, virus-induced episodes of wheeze who were able to perform acceptable fraction of exhaled nitric oxide (Feno) maneuvers and spirometry (with forced expiratory time ≥0.5 seconds) were followed prospectively. Lung function and Feno values were measured every 6 weeks (baseline) within the first 48 hours of an acute wheezing episode (day 0) and 10 and 30 days later. Symptom scores and peak flow measurement were recorded daily. Results Forty-three children experienced a wheezing episode. At day 0, Feno values were significantly increased, whereas forced expiratory volume at 0.5 seconds (FEV0.5) significantly decreased compared with baseline (16 ppb [interquartile range {IQR}, 13-20 ppb] vs 9 ppb IQR, 7-11 ppb] and 0.84 L [IQR, 0.75-0.99 L] vs 0.99 L [IQR, 0.9-1.07 L], respectively; both P < .001). Airflow limitation at day 0 was reversible after bronchodilation. FEV0.5 and Feno values were significantly associated with each other and with lower and upper respiratory tract symptoms when assessed longitudinally but not cross-sectionally at all time points independently of atopy. Feno and FEV0.5 values returned to baseline levels within 10 days. Conclusions Mild episodes of wheeze in preschoolers are characterized by enhanced airway inflammation, reversible airflow limitation, and asthma-related symptoms. Feno values increase significantly during the first 48 hours and return to personal baseline within 10 days from the initiation of the episode. Longitudinal follow-up suggests that symptoms, inflammation, and lung function correlate well in this phenotype of asthma.
has issue date	2013-01-31(xsd:dateTime)
bibo:doi	10.1016/j.jaci.2012.10.033
bibo:pmid	23199600
has license	els-covid
sha1sum (hex)	7dd00e91d390920a61a08b760011d3a30c9da921
schema:url	https://doi.org/10.1016/j.jaci.2012.10.033
resource representing a document's title	Assessment of airflow limitation, airway inflammation, and symptoms during virus-induced wheezing episodes in 4- to 6-year-old children
has PubMed Central identifier	PMC7112251
has PubMed identifier	23199600
schema:publication	Journal of Allergy and Clinical Immunology
resource representing a document's body	covid:7dd00e91d390920a61a08b760011d3a30c9da921#body_text
is schema:about of	named entity 'DISPUTED' named entity 'RESULTS' named entity 'SYMPTOMS' named entity 'FORTY-THREE' named entity 'PERSONAL' named entity 'WHEEZE' named entity 'RECURRENT' named entity 'INCREASE' named entity 'FORCED EXPIRATORY TIME' named entity 'INDUCED' named entity 'YEARS' named entity 'RANGE' named entity '48 HOURS' named entity 'INFLAMMATION' named entity 'FOLLOW-UP' named entity 'SYMPTOM' named entity 'DECREASED' named entity 'FRACTION OF EXHALED NITRIC OXIDE' named entity 'LUNG FUNCTION' named entity 'CONCLUSIONS' named entity 'ASSESS' named entity 'CHARACTERIZED' named entity 'FOLLOWED' named entity 'COMPRISE' named entity 'UPPER RESPIRATORY TRACT SYMPTOMS' named entity 'EPISODE' named entity 'BASELINE' named entity 'EPISODIC' named entity 'EVERY 6 WEEKS' named entity 'AGED' named entity 'exhaled nitric oxide' named entity 'lung function' named entity 'phenotype' named entity 'history' named entity 'episodes' named entity 'day' named entity 'baseline' named entity 'RETURNED' named entity 'LEVELS' named entity 'ENHANCED' named entity 'CROSS' named entity 'FEV' named entity 'YEAR' named entity 'INDUCED' named entity 'OLD' named entity 'FORCED EXPIRATORY VOLUME' named entity 'PRESCHOOLERS' named entity 'DAILY' named entity 'SECONDS' named entity 'IMMUNOL' named entity 'OBJECTIVE' named entity '0.5' named entity '0.99' named entity 'AIRFLOW LIMITATION' named entity 'WHEEZING' named entity 'BRONCHODILATION' named entity 'LATER' named entity 'PRESCHOOL' named entity 'LOWER' named entity 'AIRWAY INFLAMMATION' named entity 'EPISODES' named entity 'WHEEZING' named entity 'VIRUS' named entity 'AIRFLOW LIMITATION' named entity 'ASSESSMENT' named entity 'PERFORM' named entity 'EXPERIENCED' named entity 'EPISODES' named entity 'ASTHMA' named entity 'CHILDREN' named entity 'HISTORY OF' named entity 'DAYS' named entity 'FENO'

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