About: Biological targets for isatin and its analogues: Implications for therapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Biological targets for isatin and its analogues: Implications for therapy
Creator	Buneeva, Olga Glover, Vivette Medvedev, Alexei
Source	Medline; PMC
abstract	Isatin and its metabolites are constituents of many natural substances. They are also components of many synthetic compounds exhibiting a wide range of effects, including antiviral activity, antitumor and antiangiogenic activity, antibacterial, antitubercular, antifungal, antiaptotic, anticonvulsant and anxyolytic activities. Isatin itself is an endogenous oxidized indole with a wide spectrum of behavioral and metabolic effects. It has a distinct and discontinuous distribution in the brain, peripheral tissues and body fluids and isatin binding sites are widely distributed also. Its output is increased during stress. Its most potent known in vitro actions are as an antagonist of atrial natriuretic peptide (ANP) function and NO signaling. As we understand more about its function and sites of action we may be able to develop new pharmacological agents to mimic or counteract its activity. We consider here the most promising biological targets for various isatin analogues and/or metabolites, which are employed for the development of various groups of therapeutics. It is also possible that the level of endogenous isatin may influence the in vivo pharmacological activity of compounds possessing the isatin moiety.
has issue date	2007-06-01(xsd:dateTime)
bibo:pmid	19707325
has license	no-cc
sha1sum (hex)	7e4f3fdf70d647d0530a94f12f90f0927fbc1ff5
resource representing a document's title	Biological targets for isatin and its analogues: Implications for therapy
has PubMed Central identifier	PMC2721300
has PubMed identifier	19707325
schema:publication	Biologics
resource representing a document's body	covid:7e4f3fdf70d647d0530a94f12f90f0927fbc1ff5#body_text
is schema:about of	named entity 'moiety' named entity 'pharmacological activity' named entity 'sites' named entity 'peripheral' named entity 'indole' named entity 'activity' named entity 'ACTION' named entity 'DURING STRESS' named entity 'IN VIVO' named entity 'EMPLOYED' named entity 'ACTIONS' named entity 'UNDERSTAND' named entity 'EFFECTS' named entity 'MAY BE' named entity 'ANTAGONIST' named entity 'BINDING SITES' named entity 'THE BRAIN' named entity 'BODY' named entity 'POSSIBLE' named entity 'ACTIVITY' named entity 'ANTITUBERCULAR' named entity 'NEW' named entity 'NATURAL' named entity 'FUNCTION' named entity 'ANTITUMOR' named entity 'COMPONENTS' named entity 'DISTRIBUTED' named entity 'ITS' named entity 'BIOLOGICAL' named entity 'METABOLIC EFFECTS' named entity 'ISATIN' named entity 'TARGETS' named entity 'ANTIANGIOGENIC' named entity 'DISTRIBUTION' named entity 'BIOLOGICAL' named entity 'ENDOGENOUS' named entity 'ANTIVIRAL ACTIVITY' named entity 'TARGETS' named entity 'MOIETY' named entity 'DEVELOPMENT' named entity 'PHARMACOLOGICAL' named entity 'MIMIC' named entity 'SITES' named entity 'ABOUT' named entity 'SUBSTANCES' named entity 'SYNTHETIC' named entity 'PHARMACOLOGICAL ACTIVITY' named entity 'INDOLE' named entity 'VARIOUS' named entity 'WIDE' named entity 'CONSIDER' named entity 'ITS' named entity 'BEHAVIORAL' named entity 'CONSTITUENTS' named entity 'KNOWN' named entity 'DISCONTINUOUS' named entity 'THERAPEUTICS' named entity 'SPECTRUM' named entity 'METABOLITES' named entity 'ANTIFUNGAL' named entity 'HERE' named entity 'GROUPS' named entity 'DISTINCT' named entity 'ANTIBACTERIAL' named entity 'LEVEL' named entity 'ACTIVITIES' named entity 'IN VITRO' named entity 'RANGE' named entity 'PERIPHERAL' named entity 'ATRIAL NATRIURETIC PEPTIDE' named entity 'SIGNALING' named entity 'OXIDIZED' named entity 'ANTICONVULSANT' named entity 'TISSUES' named entity 'OUTPUT' named entity 'FOR THERAPY' named entity 'INCREASED' named entity 'EXHIBITING' named entity 'ISATIN' named entity 'INCLUDING' named entity 'metabolites'

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