About: Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19)
Creator	Pletschette, Michel Hoelscher, Michael Rothe, Camilla Bakuli, Abhishek Hermann, Thomas Schunk, Mirjam Thiel, Verena Wallrauch, Claudia Zimmer, Thorbjörn Baldassarre, Valeria Baumann, Elias Brand, Isabel Britz, Eva Böhnlein, Flora Caroli, Niklas Deak, Lara Dech, Emma Dech, Laura Diefenbach, Max Do, Sophie Eckstein, Judith Falk, Philine Fischer, Stefanie Forster, Felix Froeschl, Günter Frese, Jonathan Gasser, Marius Gauder, Sonja Geisenberger, Otto Geldmacher, Christof Gilberg, Matthias Gillig, Kristina Golschan, Vitus Grauvogel, Vera Grauvogl, Vitus Guggenbühl Noller, Jessica Haselwarter, Maximilian Haselwarter, Tim-Oliver Heiber, Arlett Hillmann, Stefan Hoffmann, Larissa Hoefflin, Jeni Hofberger, Tim Huber, Kristina Höfinger, Michael Kiani, Charlotte Klugherz, Isabel Kreider, Norah Kroidl, Inge Lang, Clemens Lang, Magdalena Lange, Silvan Lapteva, Tim Lindner, Maczka, Alexander Markgraf, Alisa Matcau, Paula Metaxa, Dafni Müller, Hannah Ngoc-Nhu, Anna Olbrich, Laura Pattard, Leonie Pleimelding, Claire-Sophie Pritsch, Michael Puchinger, Kerstin Pusl, Konstantin Radon, Katja Raschka, Julius Reich, Leonard Riess, Friedrich Saathoff, Elmar Schandelmaier, Patrick Schneider, Jakob Scholz, Marco Schultz, Ekaterina Tang, Julia Theis, Fabian Thumser, Paul Thur, Felix Ullrich, Julian Wieser, Andreas Wolff, Rebecca Wustrow, Lea Würfel, Tobias Zimmermann, Friedrich Zuche, Janna
Source	Medline; PMC
abstract	BACKGROUND: Due to the SARS-CoV-2 pandemic, public health interventions have been introduced globally in order to prevent the spread of the virus and avoid the overload of health care systems, especially for the most severely affected patients. Scientific studies to date have focused primarily on describing the clinical course of patients, identifying treatment options and developing vaccines. In Germany, as in many other regions, current tests for SARS-CoV2 are not conducted on a representative basis and in a longitudinal design. Furthermore, knowledge about the immune status of the population is lacking. Nonetheless, these data are needed to understand the dynamics of the pandemic and hence to appropriately design and evaluate interventions. For this purpose, we recently started a prospective population-based cohort in Munich, Germany, with the aim to develop a better understanding of the state and dynamics of the pandemic. METHODS: In 100 out of 755 randomly selected constituencies, 3000 Munich households are identified via random route and offered enrollment into the study. All household members are asked to complete a baseline questionnaire and subjects ≥14 years of age are asked to provide a venous blood sample of ≤3 ml for the determination of SARS-CoV-2 IgG/IgA status. The residual plasma and the blood pellet are preserved for later genetic and molecular biological investigations. For twelve months, each household member is asked to keep a diary of daily symptoms, whereabouts and contacts via WebApp. If symptoms suggestive for COVID-19 are reported, family members, including children < 14 years, are offered a pharyngeal swab taken at the Division of Infectious Diseases and Tropical Medicine, LMU University Hospital Munich, for molecular testing for SARS-CoV-2. In case of severe symptoms, participants will be transferred to a Munich hospital. For one year, the study teams re-visits the households for blood sampling every six weeks. DISCUSSION: With the planned study we will establish a reliable epidemiological tool to improve the understanding of the spread of SARS-CoV-2 and to better assess the effectiveness of public health measures as well as their socio-economic effects. This will support policy makers in managing the epidemic based on scientific evidence.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1186/s12889-020-09164-9
bibo:pmid	32605549
has license	cc-by
sha1sum (hex)	7e97f0e86c26dcb300aa58e766c14eec990e2584
schema:url	https://doi.org/10.1186/s12889-020-09164-9
resource representing a document's title	Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19)

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