About: Recombinant vesicular stomatitis virus expressing the spike protein of genotype 2b porcine epidemic diarrhea virus: A platform for vaccine development against emerging epidemic isolates

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About: Recombinant vesicular stomatitis virus expressing the spike protein of genotype 2b porcine epidemic diarrhea virus: A platform for vaccine development against emerging epidemic isolates Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recombinant vesicular stomatitis virus expressing the spike protein of genotype 2b porcine epidemic diarrhea virus: A platform for vaccine development against emerging epidemic isolates
Creator	Sun, Tao Wang, Xiaoyu Fang, Xinkui Gao, Jing Ke, Yong Wang, Hengan Yu, Dayi Zhang, Fanqing
Source	Elsevier; Medline; PMC
abstract	Abstract Emerging porcine epidemic diarrhea viruses (PEDVs) have caused large economic losses since 2010, and G2b is the prevalent globally epidemic genotype. Given the fastidious isolation of emerging PEDV in cell culture and difficulties in retaining the isolate infectivity upon further in vitro passage, highly attenuated recombinant vesicular stomatitis virus (rVSVMT) was used as a vector to express the PEDV spike (S) protein, aiming to develop a subunit vaccine against G2b viruses. An S protein with 19 of its cytoplasmic domain amino acids deleted could be incorporated into VSV particles, generating rVSVMT (VSVMT-SΔ19) with high efficiency. Our results suggest that VSVMT-SΔ19 could effectively induce PEDV-specific immunity in pigs via intramuscular, but not intranasal, immunization. Notably, immunizations of sows with VSV MT-SΔ19 provided protective lactogenic immunity against a virulent G2b PEDV challenge in piglets. Consequently, recombinant VSVMT may be a promising platform for preparing a subunit vaccine against PEDV.
has issue date	2019-07-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2019.05.009
bibo:pmid	31128495
has license	els-covid
sha1sum (hex)	7f3ca4133a2788e02072b7c38d2fd7dca26b7458
schema:url	https://doi.org/10.1016/j.virol.2019.05.009
resource representing a document's title	Recombinant vesicular stomatitis virus expressing the spike protein of genotype 2b porcine epidemic diarrhea virus: A platform for vaccine development against emerging epidemic isolates
has PubMed Central identifier	PMC7112030
has PubMed identifier	31128495
schema:publication	Virology
resource representing a document's body	covid:7f3ca4133a2788e02072b7c38d2fd7dca26b7458#body_text
is schema:about of	named entity 'G2b' named entity 'viruses' named entity 'globally' named entity 'isolates' named entity 'genotype' named entity 'LARGE' named entity 'MAY BE A' named entity 'RECOMBINANT' named entity 'ATTENUATED' named entity 'IN VITRO' named entity 'BUT' named entity 'IMMUNITY' named entity 'DIFFICULTIES' named entity 'PLATFORM' named entity 'PROTEIN' named entity 'ISOLATION' named entity 'CAUSED' named entity 'USED' named entity 'ISOLATE' named entity 'PARTICLES' named entity 'CYTOPLASMIC DOMAIN' named entity 'EPIDEMIC' named entity 'PASSAGE' named entity 'COULD BE' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'ISOLATES' named entity 'PLATFORM' named entity 'GENOTYPE' named entity 'ECONOMIC' named entity 'SOWS' named entity '28S' named entity 'EPIDEMIC' named entity 'PROTEIN ' named entity 'VACCINE DEVELOPMENT' named entity 'SPIKE PROTEIN' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'SPECIFIC IMMUNITY' named entity 'HIGH EFFICIENCY' named entity 'SUGGEST' named entity 'INTRAMUSCULAR' named entity 'PEDV' named entity 'INDUCE' named entity 'IMMUNIZATION' named entity 'HIGHLY' named entity 'GENERATING' named entity 'INTRANASAL' named entity 'VECTOR' named entity 'GLOBALLY' named entity 'GIVEN' named entity 'IMMUNIZATIONS' named entity 'PORCINE EPIDEMIC DIARRHEA' named entity 'GENOTYPE' named entity '9419' named entity 'PROVIDED' named entity 'DELETED' named entity 'VIRULENT' named entity 'SUBUNIT VACCINE' named entity 'RECOMBINANT' named entity 'RVSV' named entity 'CHALLENGE' named entity 'RESULTS' named entity 'TO EXPRESS' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'RETAINING' named entity 'OUR' named entity 'HAVE' named entity 'PIGS' named entity 'INFECTIVITY' named entity 'PREVALENT' named entity 'SPIKE' named entity 'S PROTEIN' named entity 'ITS' named entity 'CELL CULTURE' named entity 'VIRUSES'

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