About: Polymorphisms in the Mannan-Binding Lectin Gene Are Not Associated with Questionnaire-Reported Respiratory Tract Infections in Children

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Polymorphisms in the Mannan-Binding Lectin Gene Are Not Associated with Questionnaire-Reported Respiratory Tract Infections in Children
Creator	Sanders, Elisabeth Bottema, Renske Brunekreef, Bert De Jongste, Johan Hoekstra, Maarten Kerkhof, Marjan Koppelman, Gerard Postma, Dirkje Rovers, Maroeska Ruskamp, Jopje Wijga, Alet
source	Medline; PMC
abstract	Background. Low mannan-binding lectin (MBL) levels, caused by MBL2 polymorphisms, are suggested to contribute to susceptibility to respiratory tract infections (RTIs), particularly early in life. Large-scale replication of previous associations is needed, however. We investigated the association between MBL2 polymorphisms and the frequency of RTI in a large population-based birth cohort of white children. Methods. The frequency of RTI was prospectively assessed by annual parental questionnaires until children were 4 years of age. Thirteen polymorphisms in MBL2 were determined in 987 Dutch children. Haplotypes, previously shown to be associated with functional levels of MBL, were constructed, and their associations with the frequency of RTI during year 1, year 2, and the first 4 years of life were assessed. High-producing, intermediate-producing, and deficient MBL2 genotypes were defined on the basis of exon 1 and Y/X promoter polymorphisms. Results. No differences were found between investigated polymorphisms and haplotype frequencies in the population as a whole or between the groups with frequent, moderately frequent, or no RTIs reported. Deficient MBL2 genotypes were not associated with an increased risk of RTI (odds ratio, 0.71 [95% confidence interval, 0.25 to 2.05]) during years 1–4 of life. This was also true when year 1 and year 2 were studied separately. Conclusion. These results suggest that, at the population level, MBL2 polymorphisms do not contribute to the risk of questionnaire-reported RTI in white children.
has issue date	2008-12-01(xsd:dateTime)
bibo:doi	10.1086/592989
bibo:pmid	18847375
has license	no-cc
sha1sum (hex)	7f67766814dbcedf511eafe5b6348d87d082815a
schema:url	https://doi.org/10.1086/592989
resource representing a document's title	Polymorphisms in the Mannan-Binding Lectin Gene Are Not Associated with Questionnaire-Reported Respiratory Tract Infections in Children
has PubMed Central identifier	PMC7109965
has PubMed identifier	18847375
schema:publication	J Infect Dis
resource representing a document's body	covid:7f67766814dbcedf511eafe5b6348d87d082815a#body_text
is schema:about of	named entity 'polymorphisms' named entity 'RTI' named entity 'CHILDREN' named entity 'NEEDED' named entity 'INVESTIGATED' named entity 'MANNAN-BINDING LECTIN' named entity 'EARLY' named entity 'LARGE' named entity 'BIRTH COHORT' named entity 'SCALE' named entity 'ASSOCIATIONS' named entity 'WHITE' named entity 'PREVIOUS' named entity 'LIFE' named entity 'RTI' named entity 'POPULATION-BASED' named entity 'LOW' named entity 'QUESTIONNAIRE' named entity 'GENE' named entity 'CAUSED BY' named entity 'REPLICATION' named entity 'ASSOCIATION' named entity 'POLYMORPHISMS' named entity 'ASSOCIATED WITH' named entity 'MANNAN-BINDING LECTIN' named entity 'POLYMORPHISMS' named entity 'REPORTED' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'CONTRIBUTE ' named entity 'LEVELS' named entity 'CHILDREN' named entity 'BACKGROUND' named entity 'FREQUENCY' named entity 'MBL2' named entity 'SUSCEPTIBILITY' covid:arg/7f67766814dbcedf511eafe5b6348d87d082815a named entity 'associations' named entity 'polymorphisms' named entity 'caused' named entity 'Respiratory' named entity 'polymorphisms' named entity 'respiratory tract infections' named entity 'mannan-binding lectin' named entity 'MBL2' named entity 'Respiratory Tract Infections' named entity 'minor allele frequency' named entity 'polymorphisms' named entity 'genotyping' named entity 'polymorphisms' named entity '2-propanol' named entity 'genotype' named entity 'study population' named entity 'acute respiratory infections' named entity 'MBL2' named entity 'MBL2' named entity 'Greenland' named entity 'asthma' named entity 'ordinal regression' named entity 'genetic study' named entity 'severe infections' named entity 'genetic control' named entity 'multimers' named entity 'neuraminidase' named entity 'haplotypes' named entity 'exon' named entity 'birth cohort' named entity 'alleles' named entity 'MBL' named entity 'study population' named entity 'breast-feeding'

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