About: Neutrophil survival factors (TNF-alpha, GM-CSF, and G-CSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions

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About: Neutrophil survival factors (TNF-alpha, GM-CSF, and G-CSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Neutrophil survival factors (TNF-alpha, GM-CSF, and G-CSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions
Creator	Hohdatsu, Tsutomu Takano, Tomomi Hashida, Yoshikiyo Ae, Azuma Ae, Satoh Ae, Toda Ayako, A Natsuko, A Ryoichi, A Satoh, Miyuki
source	Medline; PMC
abstract	Feline infectious peritonitis (FIP) is a feline coronavirus (FCoV)-induced fatal disease of domestic and wild cats. The infiltration of neutrophils into granulomatous lesions is unusual for a viral disease, but it is a typical finding of FIP. This study aimed to investigate the reason for the lesions containing neutrophils in cats with FIP. Neutrophils of cats with FIP were cultured, and changes in the cell survival rate were assessed. In addition, the presence or absence of neutrophil survival factors was investigated in specimens collected from cats with FIP. Furthermore, it was investigated whether macrophages, one of the target cells of FIPV infection, produce neutrophil survival factors (TNF-alpha, GM-CSF, and G-CSF). We showed that virus-infected macrophages overproduce neutrophil survival factors, and these factors act on neutrophils and up-regulate their survival. These observations suggest that sustained production of neutrophil survival factors by macrophages during FCoV infection is sufficient for neutrophil survival and contributes to development of granulomatous lesions.
has issue date	2009-04-03(xsd:dateTime)
bibo:doi	10.1007/s00705-009-0371-3
bibo:pmid	19343474
has license	no-cc
sha1sum (hex)	8053c5eb9a0e8e0c41c12bf072c8e19607ffa527
schema:url	https://doi.org/10.1007/s00705-009-0371-3
resource representing a document's title	Neutrophil survival factors (TNF-alpha, GM-CSF, and G-CSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions
has PubMed Central identifier	PMC7086964
has PubMed identifier	19343474
schema:publication	Arch Virol
resource representing a document's body	covid:8053c5eb9a0e8e0c41c12bf072c8e19607ffa527#body_text
is schema:about of	named entity 'G-CSF' named entity 'peritonitis' named entity 'cultured' named entity 'neutrophil' named entity 'cats' named entity 'neutrophils' named entity 'typical' named entity 'GM-CSF' named entity 'macrophages' named entity 'peritonitis' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'TO INVESTIGATE' named entity 'SPECIMENS' named entity 'THESE' named entity 'INFILTRATION' named entity 'FATAL DISEASE' named entity 'INFECTION' named entity 'NEUTROPHIL' named entity 'DEVELOPMENT' named entity 'SURVIVAL' named entity 'ADDITION' named entity 'TARGET CELLS' named entity 'ALPHA' named entity 'STUDY' named entity 'VIRUS' covid:arg/8053c5eb9a0e8e0c41c12bf072c8e19607ffa527 named entity 'ALPHA' named entity 'PATHOGENESIS' named entity 'SURVIVAL' named entity 'MACROPHAGES' named entity 'NEUTROPHIL' named entity 'CULTURED' named entity 'WILD' named entity 'GRANULOMATOUS LESIONS' named entity 'CONTRIBUTE ' named entity 'GM-CSF' named entity 'INFECTED' named entity 'CATS' named entity 'NEUTROPHILS' named entity 'CELL SURVIVAL RATE' named entity 'COLLECTED' named entity 'UNUSUAL' named entity 'PRESENCE' named entity 'PRODUCTION' named entity 'SUGGEST' named entity 'SUSTAINED' named entity 'LESIONS' named entity 'FIPV' named entity 'CHANGES' named entity 'IS A' named entity 'GRANULOMATOUS LESIONS' named entity 'INVESTIGATED' named entity 'VIRAL DISEASE' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'FIP' named entity 'INDUCED' named entity 'THEIR' named entity 'CATS' named entity 'ONE OF' named entity 'BUT' named entity 'ASSESSED' named entity 'REASON FOR' named entity 'CONTAINING' named entity 'G-CSF' named entity 'ACT' named entity 'THE CELL' named entity 'MACROPHAGES' named entity 'TYPICAL' named entity 'FINDING' named entity 'GM-CSF' named entity 'FELINE CORONAVIRUS' named entity 'ABSENCE OF'

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