About: Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance
Creator	Beltrán-García, Jesús Luis García-Giménez, José Nacher-Sendra, Elena Osca-Verdegal, Rebeca Pallardó, Federico
Source	Medline; PMC
abstract	Sepsis is a life-threatening condition that occurs when the body responds to an infection that damages it is own tissues. The major problem in sepsis is rapid, vital status deterioration in patients, which can progress to septic shock with multiple organ failure if not properly treated. As there are no specific treatments, early diagnosis is mandatory to reduce high mortality. Despite more than 170 different biomarkers being postulated, early sepsis diagnosis and prognosis remain a challenge for clinicians. Recent findings propose that circular RNAs (circRNAs) may play a prominent role in regulating the patients’ immune system against different pathogens, including bacteria and viruses. Mounting evidence also suggests that the misregulation of circRNAs is an early event in a wide range of diseases, including sepsis. Despite circRNA levels being altered in sepsis, the specific mechanisms controlling the dysregulation of these noncoding RNAs are not completely elucidated, although many factors are known to affect circRNA biogenesis. Therefore, there is a need to explore the molecular pathways that lead to this disorder. This review describes the role of this new class of regulatory RNAs in sepsis and the feasibility of using circRNAs as diagnostic biomarkers for sepsis, opening up new avenues for circRNA-based medicine.
has issue date	2020-06-25(xsd:dateTime)
bibo:doi	10.3390/cells9061544
bibo:pmid	32630422
has license	cc-by
sha1sum (hex)	81cb93664da80088404d6d7a363e9f1d690e45b6
schema:url	https://doi.org/10.3390/cells9061544
resource representing a document's title	Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance
has PubMed Central identifier	PMC7349763
has PubMed identifier	32630422
schema:publication	Cells
resource representing a document's body	covid:81cb93664da80088404d6d7a363e9f1d690e45b6#body_text
is schema:about of	named entity 'CONTROLLING' named entity 'MANDATORY' named entity 'MOLECULAR PATHWAYS' named entity 'RECENT' named entity 'THESE' named entity 'CIRCULAR' named entity 'MEDICINE' named entity 'MECHANISMS' named entity 'LEAD' named entity 'DIAGNOSTIC' named entity 'FEASIBILITY' named entity 'BODY' named entity 'PROGRESS' named entity 'exonucleases' named entity 'sepsis' named entity 'phenotype' named entity 'polyacrylamide gel electrophoresis' named entity 'protein-coding gene' named entity 'cytokines' named entity 'TET1' named entity 'IL-30' named entity 'prognosis' named entity 'infection' named entity 'Sepsis' named entity 'circRNA' named entity 'sepsis' named entity 'pathogens' named entity 'viruses' named entity 'sepsis' named entity 'sepsis' named entity 'biomarkers' named entity 'Sepsis' named entity 'Clinical Significance' named entity 'IL-6' named entity 'cytokine storm' named entity 'sepsis' named entity 'circRNA' named entity 'mRNA' named entity 'clinical practice' named entity 'sepsis' named entity 'antiviral' named entity 'ICU' named entity 'miR' named entity 'TLRs' named entity 'RNA polymerase II' named entity 'miR' named entity 'innate immunity' named entity 'spliceosome' named entity 'miR-146a' named entity 'early diagnosis' named entity 'miRNAs' named entity 'IL-1α' named entity 'innate immunity' named entity 'theranostic' named entity 'solid tumors' named entity 'circRNA' named entity 'isoforms' named entity 'sponge' named entity 'miRNAs' named entity 'RNase' named entity 'LPS' named entity 'RNase R' named entity 'immune response' named entity 'ICU' named entity 'RNA-seq' named entity 'immunosuppression' named entity 'CD4' named entity 'IL-6' named entity 'sensitivity and specificity' named entity 'sepsis' named entity 'sepsis' named entity 'immune response' named entity 'miR-29a' named entity 'intron' named entity 'regulatory RNAs' named entity 'RNA-Seq' named entity 'exonic'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software