About: Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza

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About: Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza
Creator	Ippolito, Giuseppe Agrati, Chiara Bordi, Licia Castilletti, Concetta Gioia, Cristiana Poccia, Fabrizio Puro, Vincenzo Chiappini, Roberta Piacentini, Paola Squarcione, Salvatore Tempestilli, Massimo Capobianchi, Maria
Source	PMC
abstract	Avian influenza virus (H5N1) can be transmitted to humans, resulting in a severe or fatal disease. The aim of this study was to evaluate the immune cross-reactivity between human and avian influenza (H5N1) strains in healthy donors vaccinated for seasonal influenza A (H1N1)/(H3N2). A small frequency of CD4 T cells specific for subtype H5N1 was detected in several persons at baseline, and seasonal vaccine administration enhanced the frequency of such reactive CD4 T cells. We also observed that seasonal vaccination is able to raise neutralizing immunity against influenza (H5N1) in a large number of donors. No correlation between influenza-specific CD4 T cells and humoral responses was observed. N1 may possibly be a target for both cellular and humoral cross-type immunity, but additional experiments are needed to clarify this point. These findings highlight the possibility of boosting cross-type cellular and humoral immunity against highly pathogenic avian influenza A virus subtype H5N1 by seasonal influenza vaccination.
has issue date	2008-01-01(xsd:dateTime)
bibo:doi	10.3201/eid1401.061283
bibo:pmid	18258091
has license	no-cc
sha1sum (hex)	82fb52d462dc847ed33ec87be35bd5c5065844aa
schema:url	https://doi.org/10.3201/eid1401.061283
resource representing a document's title	Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza
has PubMed Central identifier	PMC2600140
has PubMed identifier	18258091
schema:publication	Emerg Infect Dis
resource representing a document's body	covid:82fb52d462dc847ed33ec87be35bd5c5065844aa#body_text
is schema:about of	named entity 'IMMUNITY' named entity 'cellular' named entity 'strains' named entity 'infl' named entity 'H5N1' named entity 'disease' named entity 'responses' named entity 'highly' named entity 'pathogenic' named entity 'ABLE TO' named entity 'T CELLS' named entity 'BUT' named entity 'POINT' named entity 'VACCINATED' named entity 'CLARIFY' named entity 'TARGET' named entity 'SMALL' named entity 'RESULTING IN' named entity 'BASELINE' named entity 'VACCINATION' named entity 'ENHANCED' named entity 'DONORS' named entity 'CROSS' named entity 'VACCINE ADMINISTRATION' named entity 'AIM' named entity 'AVIAN' named entity 'VACCINATED' named entity 'STRAINS' named entity 'VIRUS' named entity 'OBSERVED' named entity 'PATHOGENIC' named entity 'SEVERE' named entity 'STUDY' named entity 'NUMBER OF' named entity 'BOOSTING' named entity 'CORRELATION' named entity 'CROSS' named entity 'PERSONS' named entity 'EXPERIMENTS' named entity 'HIGHLY' named entity 'SUBTYPE' named entity 'AVIAN' named entity 'CELLULAR' named entity 'REACTIVITY' named entity 'HUMORAL IMMUNITY' named entity 'RECENTLY' named entity 'SUBTYPE' named entity 'HUMANS' named entity 'FATAL DISEASE' named entity 'THESE' named entity 'ADDITIONAL' named entity 'NEEDED' named entity 'PERSONS' named entity 'REACTIVE' named entity 'TYPE' named entity 'IMMUNE' named entity 'LARGE' named entity 'H5N1' named entity 'DETECTED' named entity 'FREQUENCY' named entity 'SEASONAL' named entity 'TRANSMITTED' named entity 'CD4' named entity 'EVALUATE' named entity 'POSSIBLY' named entity 'HUMAN' named entity 'IMMUNITY' named entity 'RESPONSES' named entity 'HEALTHY' covid:arg/82fb52d462dc847ed33ec87be35bd5c5065844aa

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