About: Severe acute respiratory syndrome coronavirus‐2 may be an underappreciated pathogen of the central nervous system

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About: Severe acute respiratory syndrome coronavirus‐2 may be an underappreciated pathogen of the central nervous system Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe acute respiratory syndrome coronavirus‐2 may be an underappreciated pathogen of the central nervous system
Creator	Alam, Syed Kulka, Marianna Sandhu, Jagdeep Willows, Steven
Source	Medline; PMC
abstract	Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) causes a highly contagious respiratory disease referred to as COVID‐19. However, emerging evidence indicates that a small, but a growing number of COVID‐19 patients also manifest neurological symptoms, suggesting that SARS‐CoV‐2 may infect the nervous system under some circumstances. SARS‐CoV‐2 primarily enters the body through the epithelial lining of the respiratory and gastrointestinal tracts, but under certain conditions this pleiotropic virus may also infect peripheral nerves and gain entry into the central nervous system (CNS). The brain is shielded by various anatomical and physiological barriers, most notably the blood‐brain barrier (BBB) which functions to prevent harmful substances, including pathogens and pro‐inflammatory mediators, from entering the brain. The BBB is composed of highly specialized endothelial cells, pericytes, mast cells and astrocytes that form the neurovascular unit, which regulates BBB permeability and maintains the integrity of the CNS. In this review, we briefly discuss potential routes of viral entry and the possible mechanisms utilized by SARS‐CoV‐2 to penetrate the CNS, either by disrupting the BBB or infecting the peripheral nerves and using the neuronal network to initiate neuroinflammation. Furthermore, we speculate on the long‐term effects of SARS‐CoV‐2 infection on the brain and in the progression of neurodegenerative diseases known to be associated with other human coronaviruses. Although the mechanisms of SARS‐CoV‐2 entry into the CNS and neurovirulence are currently unknown, the potential pathways described here might pave the way for future research in this area and enable the development of better therapeutic strategies.
has issue date	2020-07-15(xsd:dateTime)
bibo:doi	10.1111/ene.14442
bibo:pmid	32668062
has license	no-cc
sha1sum (hex)	841649cbc6e3aaa02623c76cf84706ad60fd092e
schema:url	https://doi.org/10.1111/ene.14442
resource representing a document's title	Severe acute respiratory syndrome coronavirus‐2 may be an underappreciated pathogen of the central nervous system
has PubMed Central identifier	PMC7405269
has PubMed identifier	32668062
schema:publication	Eur J Neurol
resource representing a document's body	covid:841649cbc6e3aaa02623c76cf84706ad60fd092e#body_text
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