About: Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

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About: Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
Creator	Hong, Zhongsi Shan, Hong Yan, Yan Zhang, Liping Zhang, Changsheng Chen, Qiuyue Chen, Shoudeng Chen, Xiaoxue He, Suhua Huang, Zhaoxia Kang, Sisi Yang, Mei Zhou, Zhechong Zhou, Ziliang
Source	BioRxiv; MedRxiv
abstract	The outbreak of coronavirus disease (COVID-19) in China caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. It is currently no specific viral protein targeted therapeutics yet. Viral nucleocapsid protein is a potential antiviral drug target, serving multiple critical functions during the viral life cycle. However, the structural information of SARS-CoV-2 nucleocapsid protein is yet to be clear. Herein, we have determined the 2.7 Å crystal structure of the N-terminal RNA binding domain of SARS-CoV-2 nucleocapsid protein. Although overall structure is similar with other reported coronavirus nucleocapsid protein N-terminal domain, the surface electrostatic potential characteristics between them are distinct. Further comparison with mild virus type HCoV-OC43 equivalent domain demonstrates a unique potential RNA binding pocket alongside the β-sheet core. Complemented by in vitro binding studies, our data provide several atomic resolution features of SARS-CoV-2 nucleocapsid protein N-terminal domain, guiding the design of novel antiviral agents specific targeting to SARS-CoV-2.
has issue date	2020-03-07(xsd:dateTime)
bibo:doi	10.1101/2020.03.06.977876
has license	biorxiv
sha1sum (hex)	854a29cd858f64982c799eb27c0a45cb762adfa8
schema:url	https://doi.org/10.1101/2020.03.06.977876
resource representing a document's title	Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
schema:publication	bioRxiv
resource representing a document's body	covid:854a29cd858f64982c799eb27c0a45cb762adfa8#body_text
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