About: A novel submicron emulsion system loaded with vincristine–oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies

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About: A novel submicron emulsion system loaded with vincristine–oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A novel submicron emulsion system loaded with vincristine–oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies
Creator	Cao, Xi Zhang, Ting Gong, Tao Peng, Qiang Zhang, Zhirong Zheng, Yong
source	PMC
abstract	BACKGROUND: Vincristine (VCR), which is a widely used antineoplastic drug, was integrated with a submicron-emulsion drug-delivery system to enhance the anticancer effect. METHODS: After the formation of a VCR-oleic acid ion-pair complex (VCR-OA), the VCR-OA-loaded submicron emulsion (VCR-OA-SME), prepared by classical high-pressure homogenization, was characterized and its in vitro anticancer effects were evaluated. RESULTS: The submicron-emulsion formulation exhibited a homogeneous round shape. The mean particle size, zeta potential, and encapsulation efficiency were 157.6 ± 12.6 nm, −26.5 ± 5.0 mV and 78.64% ± 3.44%, respectively. An in vitro release study of the VCR-OA-SME revealed that 12.4% of the VCR was released within the first 2 hours (initial burst-release phase) and the rest of the drug was detected in the subsequent sustained-release phase. Compared with VCR solution, the pharmacokinetic study of VCR-OA-SME showed relatively longer mean residence time (mean residence time [0–∞] increased from 187.19 to 227.56 minutes), higher maximum concentration (from 252.13 ng/mL to 533.34 ng/mL), and greater area under the curve (area under the curve [0–∞] from 11,417.77 μg/L/minute to 17,164.34 μg/L/minute. Moreover, the VCR-OA-SME exhibited higher cytotoxicity (P < 0.05) on tumor cells by inducing cell arrest in the G2/M phase or even apoptosis (P < 0.05). CONCLUSION: The VCR-OA-SME formulation in our study displayed great potential for an anticancer effect for VCR.
has issue date	2013-03-20(xsd:dateTime)
bibo:doi	10.2147/ijn.s41775
bibo:pmid	23658485
has license	no-cc
sha1sum (hex)	863fec2f2894a48b0dbf00f4b934f75a002a9941
schema:url	https://doi.org/10.2147/ijn.s41775
resource representing a document's title	A novel submicron emulsion system loaded with vincristine–oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies
has PubMed Central identifier	PMC3607420
has PubMed identifier	23658485
schema:publication	Int J Nanomedicine
resource representing a document's body	covid:863fec2f2894a48b0dbf00f4b934f75a002a9941#body_text
is schema:about of	named entity 'SYSTEM' named entity 'ION' named entity 'LOADED' named entity 'VCR' named entity 'Results' named entity 'After' named entity 'efficiency' named entity 'curve' named entity 'ion-pair' named entity 'acid' named entity 'HIGHER' named entity 'EFFECT' named entity 'AREA UNDER THE CURVE' named entity '2 HOURS' named entity 'GREATER' named entity 'METHODS' named entity '12.4' named entity 'USED' named entity 'MEAN PARTICLE SIZE' named entity 'SME' named entity 'PHASE' named entity 'IN VITRO' named entity 'FORMULATION' named entity 'IN VITRO RELEASE' named entity 'SUBSEQUENT' named entity 'VINCRISTINE' named entity 'DISPLAYED' named entity 'EVALUATED' named entity '533' named entity 'ENHANCE' named entity 'SOLUTION' named entity 'CELL' named entity 'HOMOGENIZATION' named entity 'PRESSURE' named entity 'CONCLUSION' named entity 'ANTICANCER' named entity 'INDUCING' named entity 'PREPARED' named entity 'RESULTS' covid:arg/863fec2f2894a48b0dbf00f4b934f75a002a9941 named entity 'OLEIC ACID' named entity 'IN VIVO STUDIES' named entity 'BACKGROUND' named entity 'CLASSICAL' named entity 'CURVE' named entity 'ION' named entity 'PAIR' named entity 'DELIVERY SYSTEM' named entity 'EFFECT' named entity 'ENCAPSULATION EFFICIENCY' named entity 'MINUTES' named entity 'ARREST' named entity 'CYTOTOXICITY' named entity 'PHARMACOKINETIC STUDY' named entity 'RELEASED' named entity 'COMPLEX' named entity 'INCREASED' named entity 'DETECTED' named entity 'SUSTAINED' named entity 'MEAN RESIDENCE TIME' named entity 'EMULSION' named entity 'ANTICANCER' named entity 'G 2' named entity 'GREAT' named entity 'IN VITRO' named entity 'COMPLEX' named entity 'PAIR' named entity 'IMPROVED' named entity 'EMULSION' named entity 'INTEGRATED' named entity 'FORMATION' named entity 'TUMOR CELLS' named entity 'OUR' named entity 'DRUG' named entity 'REVEALED' named entity 'VCR'

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