About: Identification of Host-Immune Response Protein Candidates in the Sera of Human Oral Squamous Cell Carcinoma Patients

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About: Identification of Host-Immune Response Protein Candidates in the Sera of Human Oral Squamous Cell Carcinoma Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of Host-Immune Response Protein Candidates in the Sera of Human Oral Squamous Cell Carcinoma Patients
Creator	Chen, Y Azman, S Kerishnan, J Zain, R
source	Medline; PMC
abstract	One of the most common cancers worldwide is oral squamous cell carcinoma (OSCC), which is associated with a significant death rate and has been linked to several risk factors. Notably, failure to detect these neoplasms at an early stage represents a fundamental barrier to improving the survival and quality of life of OSCC patients. In the present study, serum samples from OSCC patients (n = 25) and healthy controls (n = 25) were subjected to two-dimensional gel electrophoresis (2-DE) and silver staining in order to identify biomarkers that might allow early diagnosis. In this regard, 2-DE spots corresponding to various up- and down-regulated proteins were sequenced via high-resolution MALDI-TOF mass spectrometry and analyzed using the MASCOT database. We identified the following differentially expressed host-specific proteins within sera from OSCC patients: leucine-rich α2-glycoprotein (LRG), alpha-1-B-glycoprotein (ABG), clusterin (CLU), PRO2044, haptoglobin (HAP), complement C3c (C3), proapolipoprotein A1 (proapo-A1), and retinol-binding protein 4 precursor (RBP4). Moreover, five non-host factors were detected, including bacterial antigens from Acinetobacter lwoffii, Burkholderia multivorans, Myxococcus xanthus, Laribacter hongkongensis, and Streptococcus salivarius. Subsequently, we analyzed the immunogenicity of these proteins using pooled sera from OSCC patients. In this regard, five of these candidate biomarkers were found to be immunoreactive: CLU, HAP, C3, proapo-A1 and RBP4. Taken together, our immunoproteomics approach has identified various serum biomarkers that could facilitate the development of early diagnostic tools for OSCC.
has issue date	2014-10-01(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0109012
bibo:pmid	25272005
has license	cc-by
sha1sum (hex)	865949791a49615aa67ae0444e5987348c82ba65
schema:url	https://doi.org/10.1371/journal.pone.0109012
resource representing a document's title	Identification of Host-Immune Response Protein Candidates in the Sera of Human Oral Squamous Cell Carcinoma Patients
has PubMed Central identifier	PMC4182798
has PubMed identifier	25272005
schema:publication	PLoS One
resource representing a document's body	covid:865949791a49615aa67ae0444e5987348c82ba65#body_text
is schema:about of	named entity 'IMMUNE RESPONSE' named entity 'patients' named entity 'haptoglobin' named entity 'serum' named entity 'sera' named entity 'CONTROLS' named entity 'ORAL SQUAMOUS CELL CARCINOMA' named entity 'ACINETOBACTER LWOFFII' named entity 'TWO-DIMENSIONAL GEL ELECTROPHORESIS' named entity 'QUALITY OF LIFE' named entity 'STUDY' named entity 'EARLY' named entity 'CANDIDATE' named entity 'APPROACH' named entity 'ASSOCIATED WITH' named entity 'EXPRESSED' named entity 'RICH' named entity '282' named entity 'MALDI-TOF MASS SPECTROMETRY' named entity 'MYXOCOCCUS XANTHUS' named entity 'EARLY STAGE' named entity 'ANALYZED' named entity 'SILVER STAINING' named entity 'NEOPLASMS' named entity 'SERUM' named entity 'HAPTOGLOBIN' named entity 'RISK FACTORS' named entity 'ALPHA-1-B-GLYCOPROTEIN' named entity 'TAKEN' named entity 'NON-' named entity 'THESE' named entity 'BACTERIAL ANTIGENS' named entity 'BURKHOLDERIA MULTIVORANS' named entity 'GLYCOPROTEIN' named entity 'SERUM BIOMARKERS' named entity 'DEVELOPMENT' named entity 'TO IDENTIFY' named entity 'FOLLOWING' named entity 'PROTEINS' named entity 'LEUCINE' named entity 'DEATH RATE' named entity 'SAMPLES' named entity 'SURVIVAL' named entity 'IMPROVING' named entity 'EARLY DIAGNOSIS' named entity 'HIGH-RESOLUTION' named entity 'ALLOW' named entity 'HOST' named entity '2-DE' named entity 'DETECTED' named entity 'RBP4' named entity 'HAP' named entity 'REGARD' named entity 'FAILURE' named entity 'BARRIER' named entity 'PROTEIN ' named entity 'PATIENTS' named entity 'SPOTS' named entity 'BIOMARKERS' named entity 'DIAGNOSTIC' named entity 'COMPLEMENT C3C' named entity 'DATABASE' named entity 'WORLDWIDE' named entity 'HEALTHY' named entity 'CLUSTERIN' named entity 'VARIOUS' named entity 'ONE OF' named entity 'OUR' named entity 'LARIBACTER HONGKONGENSIS' named entity 'IMMUNOGENICITY' named entity 'HUMAN' named entity 'IDENTIFICATION' named entity 'HOST' named entity 'OSCC' named entity 'SERA' named entity 'PRO2044' named entity 'PATIENTS' named entity 'SIGNIFICANT'

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