About: Cushing’s syndrome complicated by multiple opportunistic infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cushing’s syndrome complicated by multiple opportunistic infections
Creator	Wiersinga, W Bakker, R Gallas, P Romijn, J
source	PMC
abstract	The case history of a 56-year-old man is described who suffered from severe adrenocorticotrophic hormone (ACTH)-dependent Cushing’s syndrome. The clinical course was complicated by simultaneous infections with Pneumocystis carinii, Staphylococcus aureus, Candida albicans, Aspergillus fumigatus and Herpes simplex, which proved to be fatal. A study of the literature shows that opportunistic infections in endogenous Cushing’s syndrome are associated with severe cortisol excess and carry a high mortality. Opportunistic infections are most prevalent in the ectopic ACTH syndrome, explained by the very high plasma cortisol concentrations in this condition. Infections with Aspergillus species, Cryptoccus neoformans, Pneumocystis carinii and Nocardia asteroides predominated. Cushing’s syndrome with a very high plasma cortisol concentration causes a severe immunocompromized state. Prompt evaluation of the cause of the hypercortisolism, initiation of cortisol lowering therapy, primary prophylaxis for Pneumocystis carinii infection when plasma cortisol exceeds 2500 nmol L(−1) and a search for concomitant infectious disease is recommended.
has issue date	2014-04-09(xsd:dateTime)
bibo:doi	10.1007/bf03350337
bibo:pmid	9648056
has license	no-cc
sha1sum (hex)	8685ba4da0808749bea3142768ab9f4b7a76c775
schema:url	https://doi.org/10.1007/bf03350337
resource representing a document's title	Cushing’s syndrome complicated by multiple opportunistic infections
has PubMed Central identifier	PMC7101633
has PubMed identifier	9648056
schema:publication	J Endocrinol Invest
resource representing a document's body	covid:8685ba4da0808749bea3142768ab9f4b7a76c775#body_text
is schema:about of	named entity 'Aspergillus fumigatus' named entity 'high' named entity 'ASPERGILLUS FUMIGATUS' named entity 'CORTISOL EXCESS' named entity 'MAN' named entity 'EXPLAINED' named entity 'YEAR' named entity 'carry' named entity 'literature' named entity 'high' named entity 'ACTH' named entity 'Pneumocystis carinii' named entity 'plasma' named entity 'Aspergillus fumigatus' named entity 'Cushing's syndrome' named entity 'infection' named entity 'mmol' named entity 'potassium' named entity 'post mortem' named entity 'ketaconazole' named entity 'adrenocortical' named entity 'cortisol' named entity 'cortisol' named entity 'index finger' named entity 'ACTH' named entity 'Cushing's syndrome' named entity 'Infection' named entity 'medical history' named entity 'ACTH' named entity 'Cushing's syndrome' named entity 'endogenous' named entity 'excretion' named entity 'inflammatory response' named entity 'Pneumocystis carinii' named entity 'intubation' named entity 'dexamethasone' named entity 'endogenous' named entity 'cortisol' named entity 'muscle weakness' named entity 'suppletion' named entity 'prophylaxis' named entity 'cortisol' named entity 'Cushing's syndrome' named entity 'plasma' named entity 'pathogens' named entity 'ulcers' named entity 'infectious disease' named entity 'lung' named entity 'cortisol' named entity 'infectious disease' named entity 'ectopic ACTH syndrome' named entity 'oral dose' named entity 'abdomen' named entity 'cortisol' named entity 'blood pressure' named entity 'mmol' named entity 'Cushing's syndrome' named entity 'pneumothorax' named entity 'nitrogen' named entity 'Nocardia asteroides' named entity 'tuberculosis' named entity 'oral thrush' named entity 'lymphocytes' named entity 'cortisol' named entity 'ACTH' named entity 'infectious agents' named entity 'Pneumocystis carinii' named entity 'Aspergillus fumigatus' named entity 'carcinoid tumor' named entity 'ketoconazole' named entity 'cortisol' named entity 'plasma' named entity 'endogenous' named entity 'dexamethasone' named entity 'glucocorticoid' named entity 'creatinine' named entity 'glucose level' named entity 'ICU'

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