About: The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury

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About: The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury
Creator	Gu, Wei Zeng, Ling Du, Juan Li, Yong Jiang, Jian-Xin Li, Hai-Sheng Sun, Jian-Hui Wang, Hai-Yan Wen, Da-Lin Yang, Ce Yang, Xue-Tao Zhou, Yin-Han
Source	PMC
abstract	BACKGROUND: Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. METHODS: Based on the fact that postnatal regeneration of alveolar tissue has been attributed to alveolar epithelial cells, we established a hemorrhagic shock and Lipopolysaccharide (LPS) lung injury model. Using this model, we analyzed the cellular kinetics of lung alveolar epithelial cells. RESULTS: The results showed that alveolar epithelium type 2 cells (AEC2s) are damage resistant during acute lung injury, they might be the main cells involved in lung injury and repair. Then we observed the relationship between the expression of HGF, c-Met following ALI in rat lung and proliferation of AEC2s. The proliferation of AEC2s was inhibited when isolated primary AEC2s were co-cultured with c-Met inhibitor SU11274. Furthermore, the numbers of AEC2s was significantly decreased when ALI rats were administrated with SU11274 in vivo. It provided further evidence that the HGF/c-Met signaling plays a vital role in ALI-induced AEC2s proliferation. CONCLUSIONS: AEC2s are damage resistant during acute lung injury and the HGF/c-Met signaling pathway is of vital importance in the proliferation of AEC2s after ALI.
has issue date	2016-12-07(xsd:dateTime)
bibo:doi	10.1186/s12931-016-0480-y
bibo:pmid	27923370
has license	cc-by
sha1sum (hex)	87054575a83618fbf3efc3c46c2d84f9e468c30a
schema:url	https://doi.org/10.1186/s12931-016-0480-y
resource representing a document's title	The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury
has PubMed Central identifier	PMC5141641
has PubMed identifier	27923370
schema:publication	Respir Res
resource representing a document's body	covid:87054575a83618fbf3efc3c46c2d84f9e468c30a#body_text
is schema:about of	named entity 'epithelial cells' named entity 'tissue' named entity 'alveolar' named entity 'CELLULAR' named entity 'PROGENITOR CELLS' named entity 'ALVEOLAR EPITHELIAL CELLS' named entity 'INJURY MODEL' named entity 'METHODS' named entity 'UNKNOWN' named entity 'alveolar' named entity 'fact' named entity 'alveolar' named entity 'lung' named entity 'LPS' named entity 'stem or progenitor cells' named entity 'alveolar epithelial cells' named entity 'acute lung injury' named entity 'lung' named entity 'VEGF' named entity 'survival rate' named entity '1, 2' named entity 'endothelial' named entity 'alveoli' named entity 'stem cells' named entity 'immunofluorescence' named entity 'LTH' named entity 'lung tissue' named entity 'multipotent stem cells' named entity 'type 1' named entity 'antibodies' named entity 'ALI' named entity 'cytokine' named entity 'co-cultured' named entity 'Millipore' named entity 'Miltenyi Biotec' named entity 'lungs' named entity 'ALI' named entity 'rat' named entity 'bioengineering' named entity 'ALI' named entity 'proliferation rate' named entity 'bronchi' named entity 'ALI' named entity 'homogenate' named entity 'LPS' named entity 'influenza virus' named entity 'immunostaining' named entity 'progenitor cells' named entity 'Sprague-Dawley' named entity 'epithelial cell' named entity 'positive staining' named entity 'EDTA' named entity 'epithelial' named entity 'FcR' named entity 'c-Met' named entity 'acute lung injury' named entity 'cytokine' named entity 'positively stained' named entity 'enzyme linked immunosorbent assay' named entity 'rat' named entity 'alveolar epithelial cells' named entity 'lungs' named entity 'rat' named entity 'wt/vol' named entity 'proliferation rate' named entity 'Tween 20' named entity 'cytokines' named entity 'EGF' named entity '5.4' named entity 'homogenates'

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