About: TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus

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About: TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus
Creator	Ghasemi, Younes Hamblin, Michael Dabiri, Hamed Derakhshan, Maryam Mahjoubin-Tehran, Maryam Mirzaei, Hamed Movahedpour, Ahmad Nikoozadeh, Azin Savardashtaki, Amir Shabaninejad, Zahra Vakili, Sina Yousefi, Fatemeh
source	PMC
abstract	Cardiac fibrosis describes the inappropriate proliferation of cardiac fibroblasts (CFs), leading to accumulation of extracellular matrix (ECM) proteins in the cardiac muscle, which is found in many pathophysiological heart conditions. A range of molecular components and cellular pathways, have been implicated in its pathogenesis. In this review, we focus on the TGF-β and WNT signaling pathways, and their mutual interaction, which have emerged as important factors involved in cardiac pathophysiology. The molecular and cellular processes involved in the initiation and progression of cardiac fibrosis are summarized. We focus on TGF-β and WNT signaling in cardiac fibrosis, ECM production, and myofibroblast transformation. Non-coding RNAs (ncRNAs) are one of the main players in the regulation of multiple pathways and cellular processes. MicroRNAs, long non-coding RNAs, and circular long non-coding RNAs can all interact with the TGF-β/WNT signaling axis to affect cardiac fibrosis. A better understanding of these processes may lead to new approaches for diagnosis and treatment of many cardiac conditions.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1186/s12964-020-00555-4
has license	cc-by
sha1sum (hex)	87d6d2779247358e8c59ffe3446525d257223a3f
schema:url	https://doi.org/10.1186/s12964-020-00555-4
resource representing a document's title	TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus
has PubMed Central identifier	PMC7281690
schema:publication	Cell Commun Signal
resource representing a document's body	covid:87d6d2779247358e8c59ffe3446525d257223a3f#body_text
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