About: Emergent Large Vessel Occlusion Stroke During New York City’s COVID-19 Outbreak: Clinical Characteristics and Paraclinical Findings

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Emergent Large Vessel Occlusion Stroke During New York City’s COVID-19 Outbreak: Clinical Characteristics and Paraclinical Findings
Creator	Dangayach, Neha Dhamoon, Mandip Fara, Michael Fifi, Johanna Kummer, Benjamin Ladner, Travis Lara-Reyna, Jacques Leacy, De Majidi, Shahram Mocco, ; Oxley, Thomas Reade, ; Shigematsu, Tomoyoshi Stein, Laura Tuhrim, Stanley Weinberger, Jesse Yaeger, Kurt Yim, Benjamin
source	Medline; PMC
abstract	The 2019 novel coronavirus outbreak and its associated disease (coronavirus disease 2019 [COVID-19]) have created a worldwide pandemic. Early data suggest higher rate of ischemic stroke in severe COVID-19 infection. We evaluated whether a relationship exists between emergent large vessel occlusion (ELVO) and the ongoing COVID-19 outbreak. METHODS: This is a retrospective, observational case series. Data were collected from all patients who presented with ELVO to the Mount Sinai Health System Hospitals across New York City during the peak 3 weeks of hospitalization and death from COVID-19. Patients’ demographic, comorbid conditions, cardiovascular risk factors, COVID-19 disease status, and clinical presentation were extracted from the electronic medical record. Comparison was made between COVID-19 positive and negative cohorts. The incidence of ELVO stroke was compared with the pre-COVID period. RESULTS: Forty-five consecutive ELVO patients presented during the observation period. Fifty-three percent of patients tested positive for COVID-19. Total patients’ mean (±SD) age was 66 (±17). Patients with COVID-19 were significantly younger than patients without COVID-19, 59±13 versus 74±17 (odds ratio [95% CI], 0.94 [0.81–0.98]; P=0.004). Seventy-five percent of patients with COVID-19 were male compared with 43% of patients without COVID-19 (odds ratio [95% CI], 3.99 [1.12–14.17]; P=0.032). Patients with COVID-19 were less likely to be White (8% versus 38% [odds ratio (95% CI), 0.15 (0.04–0.81); P=0.027]). In comparison to a similar time duration before the COVID-19 outbreak, a 2-fold increase in the total number of ELVO was observed (estimate: 0.78 [95% CI, 0.47–1.08], P≤0.0001). CONCLUSIONS: More than half of the ELVO stroke patients during the peak time of the New York City’s COVID-19 outbreak were COVID-19 positive, and those patients with COVID-19 were younger, more likely to be male, and less likely to be White. Our findings also suggest an increase in the incidence of ELVO stroke during the peak of the COVID-19 outbreak.
has issue date	2020-08-17(xsd:dateTime)
bibo:doi	10.1161/strokeaha.120.030397
bibo:pmid	32755349
has license	no-cc
sha1sum (hex)	892c112a89913794866117268b53eafb5cd964d1
schema:url	https://doi.org/10.1161/strokeaha.120.030397
resource representing a document's title	Emergent Large Vessel Occlusion Stroke During New York City’s COVID-19 Outbreak: Clinical Characteristics and Paraclinical Findings
has PubMed Central identifier	PMC7434004
has PubMed identifier	32755349
schema:publication	Stroke
resource representing a document's body	covid:892c112a89913794866117268b53eafb5cd964d1#body_text
is schema:about of	named entity 'evaluated' named entity 'higher' named entity 'infection' named entity 'ongoing' named entity 'coronavirus disease 2019' named entity 'ELVO' named entity 'COVID-19 outbreak' named entity 'Previous versions' named entity 'ELVO' named entity 'NYC' named entity 'COVID-19' named entity 'myocardial infarction' named entity 'RNA virus' named entity 'platelet counts' named entity 'COVID-19 outbreak' named entity 'ejection fraction' named entity 'ELVO' named entity 'COVID' named entity 'confounding factors' named entity 'thrombectomy' named entity 'SARS-CoV' named entity 'ELVO' named entity 'posterior cerebral artery' named entity 'cardiac disease' named entity 'central nervous' named entity 'ELVO' named entity 'asymptomatic' named entity 'synaptic' named entity 'stroke symptoms' named entity 'diagnostic test' named entity 'regression analysis' named entity 'study population' named entity 'NYC' named entity 'coronavirus' named entity 'ejection fraction' named entity 'hemorrhagic stroke' named entity 'Institutional Review Board' named entity 'vessel occlusion' named entity 'cardioembolic' named entity 'COVID' named entity 'World Health Organization' named entity 'thrombus' named entity 'COVID' named entity 'diagnostic tests' named entity 'reverse-transcription polymerase chain reaction' named entity 'COVID' named entity 'COVID' named entity 'COVID-19 outbreak' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'lung' named entity 'COVID-19' named entity 'hypercoagulable state' named entity 'ELVO' named entity 'Institutional Review Board' named entity 'Stroke' named entity 'ejection fraction' named entity 'preexisting conditions' named entity 'COVID-19 disease' named entity 'D-dimer' named entity 'virus' named entity 'COVID-19 disease' named entity 'NYC' named entity 'angiotensin-converting enzyme 2'

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