About: Asymmetric expression level of clock genes in left vs. right nasal mucosa in humans with and without allergies and in rats: Circadian characteristics and possible contribution to nasal cycle

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Asymmetric expression level of clock genes in left vs. right nasal mucosa in humans with and without allergies and in rats: Circadian characteristics and possible contribution to nasal cycle Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Asymmetric expression level of clock genes in left vs. right nasal mucosa in humans with and without allergies and in rats: Circadian characteristics and possible contribution to nasal cycle
Creator	Kim, Hyun Hoon, Tae Kim, Jae Kyun, Ha Lee, Sang
source	PMC
abstract	Numerous peripheral tissues possess self-sustaining daily biologic rhythms that are regulated at the molecular level by clock genes such as PER1, PER2, CLOCK, and BMAL1. Physiological function of nasal mucosa exhibits rhythmic variability to a day-night environmental cycle. Nevertheless, little is known of the expression and distribution pattern of clock genes in nasal mucosa. The present study investigates the expression level and distribution pattern of PER1, PER2, CLOCK, and BMAL1 genes in nasal mucosa of healthy controls, allergic rhinitis patients, and normal rats. In human and rat nasal mucosa, the levels of these genes are asymmetrically expressed in nasal mucosa derived from right and left cavities in normal controls, allergic patients, and rat. In human nasal mucosa, the expression levels of these genes were higher in the decongested side than the congested mucosa. In rat nasal mucosa, these clock genes are expressed in a rhythmic circadian manner under the regular light/dark cycles. The expression levels of MUC5AC, a key mucin genes produced in superficial epithelium, are higher in decongested side than that congested side in human nasal mucosa. In rat nasal mucosa, MUC5AC levels showed a circadian rhythm which was associated with different expression levels in nasal mucosa derived from the right and left nasal cavities. Taken together with these results, the present study shows that the clock genes such as PER1, PER2, CLOCK, and BMAL1 are present in human and rat nasal mucosa, and suggest that these clock genes may control the pathophysiological function of nasal mucosa as circadian oscillators and affect the maintenance of the nasal cycle.
has issue date	2018-03-13(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0194018
bibo:pmid	29534090
has license	cc-by
sha1sum (hex)	89d27a03696c2c515c9477eb696580d6041835e0
schema:url	https://doi.org/10.1371/journal.pone.0194018
resource representing a document's title	Asymmetric expression level of clock genes in left vs. right nasal mucosa in humans with and without allergies and in rats: Circadian characteristics and possible contribution to nasal cycle
has PubMed Central identifier	PMC5849312
has PubMed identifier	29534090
schema:publication	PLoS One
resource representing a document's body	covid:89d27a03696c2c515c9477eb696580d6041835e0#body_text
is schema:about of	named entity 'regular' named entity 'manner' named entity 'side' named entity 'expression' named entity 'clock genes' named entity 'light' named entity 'level' covid:arg/89d27a03696c2c515c9477eb696580d6041835e0 named entity 'allergic rhinitis' named entity 'nasal mucosa' named entity 'nasal mucosa' named entity 'mucosa' named entity 'levels' named entity 'nasal mucosa' named entity 'study' named entity 'derived' named entity 'levels' named entity 'Physiological' named entity 'allergic' named entity 'PER1' named entity 'BMAL1' named entity 'rat' named entity 'nasal mucosa' named entity 'nasal mucosa' named entity 'BMAL1' named entity 'nasal mucosa' named entity 'rhythmic circadian' named entity 'molecular level' named entity 'PER2' named entity 'PER1' named entity 'patients' named entity 'nasal mucosa' named entity 'epithelial cells' named entity '1:500' named entity 'gene expression' named entity 'nasal cavities' named entity 'PER1' named entity 'synovial membrane' named entity 'nasal cycle' named entity 'RNA' named entity 'Santa Cruz Biotechnology' named entity 'PER2' named entity 'secretion' named entity 'antiphase' named entity 'rat' named entity 'gene expression' named entity 'PER1' named entity 'genes expression' named entity 'PER2' named entity 'plasma' named entity 'Asthma' named entity 'expression levels' named entity 'rat' named entity 'gene' named entity 'nasal mucosa' named entity 'nasal cavities' named entity 'nasal mucosa' named entity 'mucous membranes' named entity 'PER2' named entity 'PER1' named entity 'albumin' named entity 'cutaneous' named entity 'T-helper' named entity 'oscillator' named entity 'blood flow' named entity 'allergic rhinitis' named entity 'smooth muscle' named entity 'β-actin' named entity 'real time PCR' named entity 'allergic rhinitis' named entity 'mucosae' named entity 'clock genes' named entity 'respiratory mucosa' named entity 'nasal mucosa' named entity 'Windows' named entity 'chronic obstructive pulmonary disease' named entity 'PER1'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software