About: Application of next-generation sequencing technologies in virology

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Application of next-generation sequencing technologies in virology
Creator	Chantrey, Julian Chapman, David Dixon, Linda Hall, Neil Correspondence, Alan Darby, Alistair Radford, Radford, Alan
source	Medline; PMC
abstract	The progress of science is punctuated by the advent of revolutionary technologies that provide new ways and scales to formulate scientific questions and advance knowledge. Following on from electron microscopy, cell culture and PCR, next-generation sequencing is one of these methodologies that is now changing the way that we understand viruses, particularly in the areas of genome sequencing, evolution, ecology, discovery and transcriptomics. Possibilities for these methodologies are only limited by our scientific imagination and, to some extent, by their cost, which has restricted their use to relatively small numbers of samples. Challenges remain, including the storage and analysis of the large amounts of data generated. As the chemistries employed mature, costs will decrease. In addition, improved methods for analysis will become available, opening yet further applications in virology including routine diagnostic work on individuals, and new understanding of the interaction between viral and host transcriptomes. An exciting era of viral exploration has begun, and will set us new challenges to understand the role of newly discovered viral diversity in both disease and health.
has issue date	2012-09-01(xsd:dateTime)
bibo:doi	10.1099/vir.0.043182-0
bibo:pmid	22647373
has license	cc-by
sha1sum (hex)	8a2b2c72af5a57c21d912a3f1e543bcd75345883
schema:url	https://doi.org/10.1099/vir.0.043182-0
resource representing a document's title	Application of next-generation sequencing technologies in virology
has PubMed Central identifier	PMC3709572
has PubMed identifier	22647373
schema:publication	J Gen Virol
resource representing a document's body	covid:8a2b2c72af5a57c21d912a3f1e543bcd75345883#body_text
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