About: Virus detection and cytokine profile in relation to age among acute exacerbations of childhood asthma

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About: Virus detection and cytokine profile in relation to age among acute exacerbations of childhood asthma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Virus detection and cytokine profile in relation to age among acute exacerbations of childhood asthma
Creator	Suzuki, Kazuo Hayashi, Yasuhide Kato, Masahiko Maruyama, Kenichi Mochizuki, Hiroyuki Yamada, Yoshiyuki
source	Elsevier; Medline; PMC
abstract	BACKGROUND: Little information is available regarding eosinophil activation and cytokine profiles in relation to age in virus-induced bronchial asthma. We therefore explored the association between age, respiratory viruses, serum eosinophil cationic protein (ECP), and cytokines/chemokines in acute exacerbations of childhood asthma. METHODS: We investigated viruses in nasal secretions from 88 patients with acute exacerbation of childhood asthma by using antigen detection kits and/or RT-PCR, followed by direct DNA sequencing analysis. We also measured peripheral eosinophil counts, and the serum levels of ECP and 27 types of cytokines/chemokines in 71 virus-induced acute asthma cases and 13 controls. RESULTS: Viruses were detected in 71(80.7%) of the 88 samples. The three major viruses detected were rhinoviruses, RS viruses, and enteroviruses; enteroviruses were found to be dominant in patients aged ≥3 years. There was no change in the levels of rhinoviruses and RS viruses between the two age groups, defined as children aged <3 years and children aged ≥3 years. Serum concentrations of ECP, IL-5, and IP-10 were significantly elevated in virus-induced acute asthma cases compared with controls. Serum ECP values were significantly higher in patients with virus-induced asthma at age ≥3 years compared with those aged <3 years. Among the 27 cytokines/chemokines, serum IP-10 was significantly higher in virus-induced asthma in patients <3 years than in those ≥3 years. Serum ECP and IL-5 production correlated significantly with age, whereas serum IP-10 showed an inverse correlation with age. CONCLUSIONS: Age-related differences in cytokine profiles and eosinophil activation may be related to virus-induced acute exacerbations of childhood asthma.
has issue date	2015-08-04(xsd:dateTime)
bibo:doi	10.1016/j.alit.2015.06.008
bibo:pmid	26344082
has license	no-cc
sha1sum (hex)	8b60020c52271ad90216c7d6f5f2889285eff786
schema:url	https://doi.org/10.1016/j.alit.2015.06.008
resource representing a document's title	Virus detection and cytokine profile in relation to age among acute exacerbations of childhood asthma
has PubMed Central identifier	PMC7110814
has PubMed identifier	26344082
schema:publication	Allergol Int
resource representing a document's body	covid:8b60020c52271ad90216c7d6f5f2889285eff786#body_text
is schema:about of	named entity 'RELATION' named entity 'ECP' named entity 'aged' named entity 'Viruses' named entity 'profiles' named entity 'viruses' named entity 'ECP' named entity 'correlated' named entity 'asthma' named entity 'respiratory' named entity 'CORRELATED' named entity 'ACUTE ASTHMA' named entity 'COUNTS' named entity 'CORRELATION' named entity 'ELEVATED' named entity 'DEFINED' named entity 'EOSINOPHIL ACTIVATION' named entity 'CHANGE IN' named entity 'VIRUS' named entity 'DOMINANT' named entity 'LEVELS' named entity 'AGE GROUPS' named entity 'MAY BE' named entity 'DNA SEQUENCING' named entity 'ECP' named entity 'ASTHMA' named entity 'SEQUENCING ANALYSIS' named entity 'AVAILABLE' named entity 'PERIPHERAL' named entity 'CYTOKINE PROFILE' covid:arg/8b60020c52271ad90216c7d6f5f2889285eff786 named entity 'FOLLOWED BY' named entity 'RHINOVIRUSES' named entity 'ACUTE EXACERBATIONS' named entity 'AGE' named entity 'VIRUS DETECTION' named entity 'CHILDHOOD ASTHMA' named entity 'ASSOCIATION' named entity 'METHODS' named entity 'RESULTS' named entity 'AGE' named entity 'INFORMATION' named entity 'IP-10' named entity 'RELATED' named entity 'ENTEROVIRUSES' named entity 'CHILDREN' named entity 'VIRUSES' named entity 'ACUTE EXACERBATION' named entity 'RELATION' named entity 'NO CHANGE' named entity 'CYTOKINE ' named entity 'COMPARED' named entity 'DETECTED' named entity 'INDUCED' named entity 'VALUES' named entity 'HIGHER' named entity 'EOSINOPHIL CATIONIC PROTEIN' named entity '2880' named entity 'INVERSE' named entity 'FOUND' named entity 'RESPIRATORY VIRUSES' named entity 'MEASURED' named entity 'AGED' named entity 'BACKGROUND' named entity 'TYPES' named entity 'CASES' named entity 'ACUTE EXACERBATIONS' named entity 'EOSINOPHIL' named entity 'INVESTIGATED' named entity 'ANTIGEN DETECTION' named entity 'BRONCHIAL ASTHMA' named entity 'RT-PCR' named entity 'CONCENTRATIONS' named entity 'CONCLUSIONS' named entity 'LITTLE' named entity 'NASAL SECRETIONS'

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