About: Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines

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About: Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines
Creator	Carralot, J.-P Hoerr, I Jung, G Pascolo, S Probst, J Rammensee, H.-G Scheel, B Teufel, R
source	PMC
abstract	In the context of developing a safe genetic vaccination strategy we tested and studied globin-stabilized mRNA-based vaccination in mice. This vaccination strategy has the advantages of genetic vaccination (easy production, adaptability to any disease and inexpensive storage when lyophilized), but not the drawbacks of DNA vaccination (long-term uncontrolled expression of a transgene, possibility of integration into the host genome and possible induction of anti-DNA antibodies). We report here that injection of naked β-globin untranslated region (UTR)-stabilized mRNA coding for β-galactosidase is followed by detectable translation in vivo. In addition, we show that such a vaccination strategy primes a T helper 2 (Th2) type of response which can be enhanced and shifted to a Th1-type immune response by application of recombinant granulocyte/macrophage colony-stimulating factor 1 day after mRNA injection. Our data demonstrate that the administration of globin UTR-stabilized mRNA is a versatile vaccination strategy that can be manipulated to fit the requirement of antiviral, antibacterial or antitumor immunity.
has issue date	2004-01-01(xsd:dateTime)
bibo:doi	10.1007/s00018-004-4255-0
bibo:pmid	15378210
has license	no-cc
sha1sum (hex)	8b89e18ac9a05967f01d204ab4afb873c5ad94d2
schema:url	https://doi.org/10.1007/s00018-004-4255-0
resource representing a document's title	Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines
has PubMed Central identifier	PMC7079797
has PubMed identifier	15378210
schema:publication	Cell Mol Life Sci
resource representing a document's body	covid:8b89e18ac9a05967f01d204ab4afb873c5ad94d2#body_text
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