About: A permanent host shift of rabies virus from Chiroptera to Carnivora associated with recombination

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About: A permanent host shift of rabies virus from Chiroptera to Carnivora associated with recombination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A permanent host shift of rabies virus from Chiroptera to Carnivora associated with recombination
Creator	Ding, Nai-Zheng He, Hong-Bin Sun, Yuan-Yuan Xu, Dong-Shuai Cheng-Qiang He, &
source	Medline; PMC
abstract	Bat virus host shifts can result in the spread of diseases with significant effects. The rabies virus (RABV) is able to infect almost all mammals and is therefore a useful model for the study of host shift mechanisms. Carnivore RABVs originated from two historical host shifts from bat viruses. To reveal the genetic pathways by which bat RABVs changed their host tropism from bats to carnivores, we investigated the second permanent bat-to-carnivore shift resulting in two carnivore variants, known as raccoon RABV (RRV) and south-central skunk RABV (SCSKV). We found that their glycoprotein (G) genes are the result of recombination between an American bat virus and a carnivore virus. This recombination allowed the bat RABV to acquire the head of the G-protein ectodomain of the carnivore virus. This region is involved in receptor recognition and binding, response to changes in the pH microenvironment, trimerization of G proteins, and cell-to-cell transmission during the viral infection. Therefore, this recombination event may have significantly improved the variant’s adaptability to carnivores, altering its host tropism and thus leading to large-scale epidemics in striped skunk and raccoon.
has issue date	2017-03-21(xsd:dateTime)
bibo:doi	10.1038/s41598-017-00395-2
bibo:pmid	28325933
has license	cc-by
sha1sum (hex)	8c71f856263c447ba7983e1f7087259008ca8505
schema:url	https://doi.org/10.1038/s41598-017-00395-2
resource representing a document's title	A permanent host shift of rabies virus from Chiroptera to Carnivora associated with recombination
has PubMed Central identifier	PMC5428239
has PubMed identifier	28325933
schema:publication	Sci Rep
resource representing a document's body	covid:8c71f856263c447ba7983e1f7087259008ca8505#body_text
is schema:about of	named entity 'CARNIVORA' named entity 'G proteins' named entity 'viruses' named entity 'recombination' named entity 'rabies' covid:arg/8c71f856263c447ba7983e1f7087259008ca8505 named entity 'HOST' named entity 'ECTODOMAIN' named entity 'GENETIC' named entity 'HISTORICAL' named entity 'TRIMERIZATION' named entity 'TROPISM' named entity 'G-PROTEIN' named entity 'SCALE' named entity 'MICROENVIRONMENT' named entity 'CELL' named entity 'KNOWN' named entity 'INVOLVED' named entity 'PROTEIN ' named entity '28G' named entity 'TRANSMISSION' named entity 'ALLOWED' named entity 'SKUNK' named entity 'RESULTING IN' named entity 'AMERICAN' named entity 'RABV' named entity 'CARNIVORE' named entity 'PATHWAYS' named entity 'USEFUL' named entity 'MAY HAVE' named entity 'STUDY' named entity 'HEAD' named entity 'OPEN' named entity 'RECOMBINATION' named entity 'SECOND' named entity 'LARGE' named entity 'INVESTIGATED' named entity 'CARNIVORES' named entity 'RECOMBINATION' named entity 'IMPROVED' named entity 'REGION' named entity 'MODEL' named entity 'ALMOST ALL' named entity 'VIRUSES' named entity 'RESULT' named entity 'PERMANENT' named entity 'BATS' named entity 'SHIFT' named entity 'ASSOCIATED WITH' named entity 'RABIES VIRUS' named entity 'ALTERING' named entity 'RECEPTOR RECOGNITION' named entity 'VARIANT' named entity 'BAT' named entity 'EPIDEMICS' named entity 'CENTRAL' named entity 'ITS' named entity 'PERMANENT' named entity 'RACCOON' named entity 'SOUTH' named entity '27S' named entity 'EVENT' named entity 'GLYCOPROTEIN' named entity 'VIRAL INFECTION' named entity 'ADAPTABILITY' named entity 'RESPONSE TO' named entity 'TO INFECT' named entity 'MECHANISMS' named entity 'SHIFT' named entity 'MAMMALS' named entity 'BINDING' named entity 'GENES' named entity 'CHIROPTERA' named entity 'VARIANTS' named entity 'VIRUS' named entity 'HOST' named entity 'FOUND'

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