About: Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China

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About: Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China
Creator	Wang, Wei Zhu, Ying Chen, Wei Huang, Meng Xie, Jianfeng Chen, Hongbin Zhao, Lin Ou, Jianming He, Wenxiang Hong, Longtao Huang, Zhimiao Wang, Jinzhang Weng, Yuwei Wu, Binshan Xiu, Wenqiong You, Libin Zhang, Canming Zhang, Yanhua Zhang, Yongjun Zheng, Kuicheng
source	PMC
abstract	This study aimed to investigate the epidemiological, clinical, and virologic characteristics of avian influenza A (H7N9) confirmed cases from two family clusters in Southeast China. Epidemiological data of the H7N9 confirmed cases and their close contacts were obtained through interviews and reviews of medical records. Of the four patients in these two family clusters, two cases had mild symptoms, one had severe symptoms, and one died. Three of the four patients had a history of exposure to live poultry or contaminated environments. The complete genome sequences of the H7N9 viruses from the same family cluster were highly homologous, and the four isolated viruses from the two family clusters exhibited the virologic features of the H7N9 virus, in terms of transmissibility, pathogenicity, host adaptation, and antiviral drug resistance. In addition, our findings indicated that the A/Fujian/18/2015 viral strain contained an additional hemagglutinin G225D substitution, which preferentially binds α2,6-linked sialic acids. The results of this study demonstrate that one family cluster was infected through common exposure to live poultry or contaminated environments, and the other was more likely to be infected through the human-to-human route.
has issue date	2017-05-04(xsd:dateTime)
bibo:doi	10.1038/s41598-017-01761-w
bibo:pmid	28473725
has license	cc-by
sha1sum (hex)	8c95cd979e4d0de0d7db26e1596919d3ffc43248
schema:url	https://doi.org/10.1038/s41598-017-01761-w
resource representing a document's title	Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China
has PubMed Central identifier	PMC5431426
has PubMed identifier	28473725
schema:publication	Sci Rep
resource representing a document's body	covid:8c95cd979e4d0de0d7db26e1596919d3ffc43248#body_text
is schema:about of	named entity 'viral strain' named entity 'Epidemiological' named entity 'viruses' named entity 'substitution' named entity 'poultry' named entity 'sequences' named entity 'family' named entity 'infections' named entity 'avian influenza' named entity 'PATIENTS' named entity 'REVIEWS' covid:arg/8c95cd979e4d0de0d7db26e1596919d3ffc43248 named entity 'medical records' named entity 'virologic' named entity 'history' named entity 'investigate' named entity 'family' named entity 'cases' named entity 'study' named entity 'demonstrate' named entity 'contaminated environments' named entity 'H7N9' named entity 'H7N9' named entity 'H7N9' named entity 'Southeast China' named entity 'virus' named entity 'contaminated environments' named entity 'H7N9' named entity 'host adaptation' named entity 'Fujian' named entity 'contaminated environments' named entity 'hemagglutinin' named entity 'virologic' named entity 'avian influenza' named entity 'RT-PCR' named entity 'cefotaxime' named entity 'H7N9' named entity 'protein' named entity 'H7N9' named entity 'genome sequences' named entity 'receptor binding' named entity 'Xiamen University' named entity 'viruses' named entity 'drug resistance' named entity 'PCR' named entity 'healthcare workers' named entity 'poultry' named entity 'genomes' named entity 'virus infection' named entity '5.5' named entity 'cefotaxime' named entity 'influenza' named entity 'Phylogenetic' named entity 'nucleotide' named entity 'GISAID' named entity 'Amino acid' named entity 'H7N9' named entity 'glycosylation' named entity 'index patient' named entity 'clinical characteristics' named entity 'H7N9' named entity 'virus infection'

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