About: Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease

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About: Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease
Creator	Evans, Claire Hobbs, Monte Horwitz, Marc Oldstone, Michael
topic	covid:8cd6d7c2eeb732eeecb6b7618d02eafe82aa62a4#this
Source	Medline; PMC
abstract	One hypothesis for the etiology of central nervous system (CNS) autoimmune disease is that infection by a virus sharing antigenic epitopes with CNS antigens (molecular mimicry) elicits a virus-specific immune response that also recognizes self-epitopes. To address this hypothesis, transgenic mice were generated that express the nucleoprotein or glycoprotein of lymphocytic choriomeningitis virus (LCMV) as self in oligodendrocytes. Intraperitoneal infection with LCMV strain Armstrong led to infection of tissues in the periphery but not the CNS, and the virus was cleared within 7–14 d. After clearance, a chronic inflammation of the CNS resulted, accompanied by upregulation of CNS expression of MHC class I and II molecules. A second LCMV infection led to enhanced CNS pathology, characterized by loss of myelin and clinical motor dysfunction. Disease enhancement also occurred after a second infection with unrelated viruses that cross-activated LCMV-specific memory T cells. These findings indicate that chronic CNS autoimmune disease may be induced by infection with a virus sharing epitopes with a protein expressed in oligodendrocytes and this disease may be enhanced by a second infection with the same or an unrelated virus. These results may explain the association of several different viruses with some human autoimmune diseases.
has issue date	1996-12-01(xsd:dateTime)
bibo:pmid	8976191
has license	cc-by-nc-sa
sha1sum (hex)	8cd6d7c2eeb732eeecb6b7618d02eafe82aa62a4
resource representing a document's title	Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease
has PubMed Central identifier	PMC2196376
has PubMed identifier	8976191
schema:publication	J Exp Med
resource representing a document's body	covid:8cd6d7c2eeb732eeecb6b7618d02eafe82aa62a4#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/8cd6d7c2eeb732eeecb6b7618d02eafe82aa62a4
is schema:about of	named entity 'LEADS' named entity 'ANTIGENS' named entity 'ADDRESS' named entity 'TRANSGENIC MICE' named entity 'LYMPHOCYTIC CHORIOMENINGITIS VIRUS' named entity 'TISSUES' named entity 'CLEARANCE' named entity 'A PROTEIN' named entity 'LCMV' named entity 'PERIPHERY' named entity 'CNS' named entity 'BUT' named entity 'NUCLEOPROTEIN' named entity 'SELF' named entity 'RECOGNIZES SELF' named entity 'CHRONIC INFLAMMATION' named entity 'ASSOCIATION' named entity 'INTRAPERITONEAL' named entity 'EXPRESSION' named entity 'GENERATED' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'SPECIFIC' named entity 'AUTOIMMUNE DISEASES' named entity 'LED' named entity 'DISEASE' named entity 'MEMORY T CELLS' named entity 'LCMV' named entity 'hypothesis' named entity 'hypothesis' named entity 'EPITOPES' named entity 'HUMAN' named entity 'CHRONIC' named entity 'ACTIVATED' named entity 'OCCURRED' named entity 'ENHANCED' named entity 'PROTEIN ' named entity 'VIRAL INFECTION' named entity 'VIRUS' named entity 'INFECTION' named entity 'ENHANCEMENT' named entity 'SHARING' named entity 'ARMSTRONG' named entity 'UNRELATED' named entity 'PROTEIN ' named entity 'CHRONIC' named entity 'TRANSGENIC MICE' named entity 'OLIGODENDROCYTES' named entity 'CENTRAL NERVOUS SYSTEM AUTOIMMUNE DISEASE' named entity 'ETIOLOGY' named entity 'MIMICRY' named entity 'CLEARED' named entity 'STRAIN' named entity 'THESE' named entity 'GLYCOPROTEIN' named entity 'RESULTS' named entity 'MOLECULES' named entity 'SPECIFIC IMMUNE RESPONSE' named entity 'INDUCED' named entity 'EXPRESS' named entity 'SECOND' named entity 'AUTOIMMUNE DISEASE' named entity 'HYPOTHESIS' named entity 'DIFFERENT' named entity 'MHC CLASS I' named entity 'MAY BE' named entity 'VIRUSES' named entity 'UPREGULATION' named entity 'VIRAL PROTEIN' named entity 'CROSS' named entity 'MOTOR DYSFUNCTION' named entity 'OLIGODENDROCYTES' named entity 'FINDINGS' named entity 'EXPRESSED' named entity 'CLINICAL' named entity 'LOSS OF MYELIN' named entity 'ELICITS' named entity 'PATHOLOGY' named entity 'CHARACTERIZED'

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