About: Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse

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About: Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse
Creator	Palau, Vanesa Pascual, Julio Riera, Marta Roca-Ho, Heleia Soler, Maria
source	PMC
abstract	Renin angiotensin system (RAS) is known to play a key role in several diseases such as diabetes, and renal and cardiovascular pathologies. Its blockade has been demonstrated to delay chronic kidney disease progression and cardiovascular damage in diabetic patients. In this sense, since local RAS has been described, the aim of this study is to characterize angiotensin converting enzyme (ACE) and ACE2 activities, as well as protein expression, in several tissues of the non-obese diabetic (NOD) mice model. After 21 or 40 days of diabetes onset, mouse serums and tissues were analyzed for ACE and ACE2 enzyme activities and protein expression. ACE and ACE2 enzyme activities were detected in different tissues. Their expressions vary depending on the studied tissue. Thus, whereas ACE activity was highly expressed in lungs, ACE2 activity was highly expressed in pancreas among the studied tissues. Interestingly, we also observed that diabetes up-regulates ACE mainly in serum, lung, heart, and liver, and ACE2 mainly in serum, liver, and pancreas. In conclusion, we found a marked serum and pulmonary alteration in ACE activity of diabetic mice, suggesting a common regulation. The increase of ACE2 activity within the circulation in diabetic mice may be ascribed to a compensatory mechanism of RAS.
has issue date	2017-03-05(xsd:dateTime)
bibo:doi	10.3390/ijms18030563
bibo:pmid	28273875
has license	cc-by
sha1sum (hex)	8da5d4c7d3f991b1538e839ed944dcd2167112d0
schema:url	https://doi.org/10.3390/ijms18030563
resource representing a document's title	Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse
has PubMed Central identifier	PMC5372579
has PubMed identifier	28273875
schema:publication	Int J Mol Sci
resource representing a document's body	covid:8da5d4c7d3f991b1538e839ed944dcd2167112d0#body_text
is schema:about of	named entity 'tissues' named entity 'diabetes' named entity 'tissues' named entity 'expressed' named entity 'ACE' covid:arg/8da5d4c7d3f991b1538e839ed944dcd2167112d0 named entity 'circulation' named entity 'ACE2' named entity 'vary' named entity 'serums' named entity 'chronic kidney disease' named entity 'mice' named entity 'liver' named entity 'ACE' named entity 'protein' named entity 'studied' named entity 'pathologies' named entity 'heart' named entity 'NOD Mouse' named entity 'Renin' named entity 'serum' named entity 'ACE' named entity 'RAS' named entity 'mice' named entity 'RAS' named entity 'ACE2' named entity 'ACE' named entity 'serum' named entity 'protein expression' named entity 'diabetic' named entity 'diabetic patients' named entity 'diabetes' named entity 'NOD' named entity 'ACE' named entity 'ACE2' named entity 'bladder' named entity 'diabetic' named entity 'dashed' named entity 'protein' named entity 'ACE' named entity 'protein expression' named entity 'protein' named entity 'mice' named entity 'choroid plexus' named entity 'ACE' named entity 'acrylamide' named entity 'Angiotensin converting enzyme' named entity 'ACE' named entity 'tissue samples' named entity 'mice' named entity 'mice' named entity 'ACE' named entity 'ACE' named entity 'protein expression' named entity 'red cross' named entity 'Barcelona' named entity 'mice' named entity 'activity assays' named entity 'fluorescent' named entity 'ACE2' named entity 'ACE' named entity 'mice' named entity 'lungs' named entity 'hydrolyzes' named entity 'RAS' named entity 'liver' named entity 'cardiac tissue' named entity 'serum' named entity 'ACE2' named entity 'blue triangle' named entity 'NOD' named entity 'liver' named entity 'total protein' named entity 'diabetes' named entity 'ACE' named entity 'blood glucose levels' named entity 'ACE2'

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