About: Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell line

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell line
Creator	Bonville, Cynthia Domachowske, Joseph Dyer, Kimberly Rosenberg, Helene Martin, Brittany Schellens, Ingrid
Source	PMC
abstract	Pneumonia virus of mice (PVM; family Paramyxoviridae, subfamily Pneumovirinae) is a natural respiratory pathogen of rodent species and an important new model for the study of severe viral bronchiolitis and pneumonia. However, despite high virus titers typically detected in infected mouse lung tissue in vivo, cell lines used routinely for virus propagation in vitro are not highly susceptible to PVM infection. We have evaluated several rodent and primate cell lines for susceptibility to PVM infection, and detected highest virus titers from infection of the mouse monocyte-macrophage RAW 264.7 cell line. Additionally, virus replication in RAW 264.7 cells induces the synthesis and secretion of proinflammatory cytokines relevant to respiratory virus disease, including tumor necrosis factor-α (TNF-α), interferon-β (IFN-β), macrophage inflammatory proteins 1α and 1β (MIP-1α and MIP-1β) and the functional homolog of human IL-8, mouse macrophage inflammatory peptide-2 (MIP-2). Identification and characterization of a rodent cell line that supports the replication of PVM and induces the synthesis of disease-related proinflammatory mediators will facilitate studies of molecular mechanisms of viral pathogenesis that will complement and expand on findings from mouse model systems.
has issue date	2007-06-04(xsd:dateTime)
bibo:doi	10.1186/1743-422x-4-48
bibo:pmid	17547763
has license	cc-by
sha1sum (hex)	8f5770d87614bb85a6c7b64c26f1757226137d23
schema:url	https://doi.org/10.1186/1743-422x-4-48
resource representing a document's title	Efficient replication of pneumonia virus of mice (PVM) in a mouse macrophage cell line
has PubMed Central identifier	PMC1891281
has PubMed identifier	17547763
schema:publication	Virol J
resource representing a document's body	covid:8f5770d87614bb85a6c7b64c26f1757226137d23#body_text
is schema:about of	named entity 'cell' named entity 'pneumonia' named entity 'detected' named entity 'TNF-α' named entity 'proinflammatory' named entity 'high' named entity 'macrophage' named entity 'rodent' named entity 'peptide' named entity 'mouse' named entity 'VIRUS REPLICATION' named entity 'TUMOR NECROSIS FACTOR' named entity 'SUSCEPTIBILITY' named entity 'MEDIATORS' named entity 'INCLUDING' named entity 'VIRAL BRONCHIOLITIS' named entity 'USED' named entity 'CELL LINE' named entity 'RESPIRATORY VIRUS' named entity 'RAW' named entity 'viral pathogenesis' named entity 'model systems' named entity 'mediators' named entity 'studies' named entity 'species' named entity 'vivo' named entity 'lung' named entity 'titers' named entity 'infection' named entity 'induces' named entity 'virus' named entity 'replication' named entity 'virus replication' named entity 'Paramyxoviridae' named entity 'rodent' named entity 'mouse model' named entity 'cell line' named entity 'peptide' named entity 'pneumonia' named entity 'Pneumovirinae' named entity 'Pneumonia' named entity 'virus disease' named entity 'cell lines' named entity 'macrophage' named entity 'Identification' named entity 'virus' named entity 'MIP-1α' named entity 'cell lines' named entity 'virus infection' named entity 'macrophage' named entity 'monocytic' named entity 'infection' named entity '1:200' named entity 'mice' named entity 'western blot' named entity 'PVM' named entity 'cell line' named entity 'molecular level' named entity 'macrophage' named entity 'hRSV' named entity 'Cytokines' named entity 'inoculum' named entity 'virus replication' named entity 'rat' named entity 'infection' named entity 'mice' named entity 'PVM' named entity 'alveolar macrophages' named entity 'inoculation' named entity 'PAF' named entity 'HEp-2' named entity 'TNF-α' named entity 'respiratory epithelial cell' named entity 'respiratory disease' named entity 'virus' named entity 'plaque assays'

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