About: Recognition of nucleic acids by pattern‐recognition receptors and its relevance in autoimmunity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recognition of nucleic acids by pattern‐recognition receptors and its relevance in autoimmunity
Creator	Akira, Shizuo Kawai, Taro Kawasaki, Takumi
Source	Medline; PMC
abstract	Summary: Host cells trigger signals for innate immune responses upon recognition of conserved structures in microbial pathogens. Nucleic acids, which are critical components for inheriting genetic information in all species including pathogens, are key structures sensed by the innate immune system. The corresponding receptors for foreign nucleic acids include members of Toll‐like receptors, RIG‐I‐like receptors, and intracellular DNA sensors. While nucleic acid recognition by these receptors is required for host defense against the pathogen, there is a potential risk to the host of self‐nucleic acids recognition, thus precipitating autoimmune and autoinflammatory diseases. In this review, we discuss the roles of nucleic acid‐sensing receptors in guarding against pathogen invasion, discriminating between self and non‐self, and contributing to autoimmunity and autoinflammatory diseases.
has issue date	2011-08-26(xsd:dateTime)
bibo:doi	10.1111/j.1600-065x.2011.01048.x
bibo:pmid	21884167
has license	no-cc
sha1sum (hex)	8fb0e21245f8359348846c34db9727f3669a4b10
schema:url	https://doi.org/10.1111/j.1600-065x.2011.01048.x
resource representing a document's title	Recognition of nucleic acids by pattern‐recognition receptors and its relevance in autoimmunity
has PubMed Central identifier	PMC7165622
has PubMed identifier	21884167
schema:publication	Immunol Rev
resource representing a document's body	covid:8fb0e21245f8359348846c34db9727f3669a4b10#body_text
is schema:about of	named entity 'SENSING' named entity 'AUTOINFLAMMATORY DISEASES' named entity 'non-self' named entity 'structures' named entity 'autoimmunity' named entity 'signals' named entity 'host defense' named entity 'Host cells' named entity 'nucleic acid' named entity 'autoimmune' named entity 'pattern-recognition' named entity 'inflammatory cytokines' named entity 'MAVS' named entity 'glucocorticoids' named entity 'cytosol' named entity 'nucleic acid' named entity 'RNA' named entity 'DHX9' named entity 'multipass' named entity 'produce antibodies' named entity 'TLR3' named entity 'TLR8' named entity 'type I IFNs' named entity 'deficient mice' named entity 'structural homology' named entity 'Newcastle disease' named entity 'Dock2' named entity 'RIG-I' named entity 'TLR8' named entity 'NLR' named entity 'autoimmunity' named entity 'IPS-1' named entity 'RNase H2' named entity 'TLR9' named entity 'negative regulators' named entity 'vesicles' named entity 'TNF' named entity 'inflammasome' named entity 'mice' named entity 'nucleic acids' named entity 'Structural analysis' named entity 'STING' named entity 'Group B Streptococcus' named entity 'cytosol' named entity 'deficient mice' named entity 'Proinflammatory cytokines' named entity 'mitochondrial membrane' named entity 'fibroblasts' named entity 'DNase' named entity 'transcription' named entity 'MyD88' named entity 'serum' named entity 'pDCs' named entity 'MyD88' named entity 'Gram-negative bacteria' named entity 'RIG-I' named entity 'cytosolic DNA sensor' named entity 'TLR4' named entity 'AIM2' named entity 'DNA viruses' named entity 'homologous' named entity 'autoimmune' named entity 'oligonucleotides' named entity 'lipid' named entity 'WNV' named entity 'RIG-I' named entity 'HMGB2' named entity 'STING' named entity 'bacteria' named entity 'RNA' named entity 'IAV' named entity 'Endosome' named entity 'cytosolic' named entity 'adaptive immune cells' named entity 'type I IFNs' named entity 'RNAs' named entity 'TLR9' named entity 'PI3K' named entity 'nucleic acids'

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