About: Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020

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About: Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020 – A cross-sectional study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020 – A cross-sectional study
Creator	Gastmeier, Petra Seybold, Joachim Hermes, Julia Mockenhaupt, Frank Behnke, Michael Burock, Susen Gertler, Maximilian Hartmann, Claudia Hommes, Franziska Kausch, Franka Kirchberger, Valerie Lindner, Andreas Maechler, Friederike Piening, Brar Rojansky, Shay Rössig, Heike Schwab, Frank Thieme, Alexander Van Loon, Welmoed
source	Elsevier; Medline; PMC
abstract	OBJECTIVE: In Berlin, the first public SARS-CoV-2 testing site started one day after the first case in the city occured. We describe epidemiological and clinical characteristics and aim at identifying risk factors for SARS-CoV-2 detection during the first six weeks of operation. METHODS: Testing followed national recommendations, but was also based on the physician´s discretion. We related patient characteristics to SARS-CoV-2 test positivity for exploratory analyses using a cross-sectional, observational study design. RESULTS: Between March 3 and April 13, 2020, 5179 patients attended the site (median age 34 years; IQR 26-47 years). The median time since disease onset was 4 days (IQR 2-7 days). Among 4333 patients tested, 333 (7.7%) were positive. Test positivity increased up to 10.3% (96/929) during the first three weeks and then declined, paralleling Germany’s lock-down and the course of the epidemic in Berlin. Strict adherence to testing guidelines resulted in 10.4% (262/2530) test positivity, compared to 3.9% (71/1803) among patients tested for other indications. A nightclub was a transmission hotspot; 27.7% (26/94) of one night’s visitors were found positive. Smell and/or taste dysfunction indicated COVID-19 with 85.6% specificity (95%CI 82.1-88.1%). Some 4% (14/333) of those infected were asymptomatic. Risk factors for detection of SARS-CoV-2 infection were recent contact to a positive case (second week after contact, OR 3.42; 95%CI 2.48-4.71), travel to regions of high pandemic activity (e.g. Austria, OR 4.16; 95%CI 2.48-6.99), recent onset of symptoms (second week, OR 3.61; 95%CI 1.87-6.98), and an impaired sense of smell/taste (4.08; 95%CI 2.36-7.03). CONCLUSIONS: In this young population, early-onset presentation of COVID-19 resembled flu-like symptoms, except for smell and/or taste dysfunction. Risk factors for SARS-CoV-2 detection were return from regions with high incidence and contact to confirmed SARS-CoV-2 cases, particularly when tests were administered within the first two weeks after contact and/or onset of symptoms.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1016/j.cmi.2020.08.017
bibo:pmid	32827715
has license	no-cc
sha1sum (hex)	92812f42649ea5b64662312accc9bc18589ebbe0
schema:url	https://doi.org/10.1016/j.cmi.2020.08.017
resource representing a document's title	Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020 – A cross-sectional study
has PubMed Central identifier	PMC7438270
has PubMed identifier	32827715
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:92812f42649ea5b64662312accc9bc18589ebbe0#body_text
is schema:about of	named entity 'testing' named entity 'Journal' named entity 'cross-sectional study' named entity 'Berlin' named entity 'March' named entity 'April' named entity 'April' named entity 'testing' named entity 'Austria' named entity 'clinical characteristics' named entity 'Berlin' named entity 'Germany' named entity 'Charité' named entity 'SARS-CoV-2' named entity 'Berlin' named entity 'polymerase chain reaction' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'Sentinel surveillance' named entity 'SARS-CoV-2' named entity 'Germany' named entity 'Italy' named entity 'cough' named entity 'RKI' named entity 'epidemic' named entity 'infection' named entity 'Charité' named entity 'pathogens' named entity 'olfactory disorders' named entity 'charite' named entity 'risk factors' named entity 'individual variation' named entity 'risk factors' named entity 'positive test' named entity 'nosocomial' named entity 'pre-test probability' named entity 'infection' named entity 'body aches' named entity 'epidemic' named entity 'epidemiological' named entity 'Charité' named entity 'community transmission' named entity 'Berlin' named entity 'China' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'clinical characteristics' named entity 'medical history' named entity 'tested positive' named entity 'Berlin' named entity 'SARS-CoV-2' named entity 'sense of smell' named entity 'Risk factors' named entity 'RKI' named entity 'Italian regions' named entity 'COVID' named entity 'March 24' named entity 'national Public Health institute' named entity 'general population' named entity 'infection' named entity 'RKI' named entity 'superspreading events' named entity 'fever'

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