About: Landscape of cohesin-mediated chromatin loops in the human genome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Landscape of cohesin-mediated chromatin loops in the human genome
Creator	Snyder, Michael Rabinovitch, Marlene Liu, Qing Sinnott-Armstrong, Nasa Kundaje, Anshul Dalton, Stephen Geller, Benjamin Greenside, Peyton Grubert, Fabian Kasowski, Maya Kulik, Michael Narasimha, Anil Ruiz-Velasco, Mariana Sa, Silin Sanghi, Akshay Spacek, Damek Srivas, Rohith Zaugg, Judith Moulton, Vera
source	PMC
abstract	Physical interactions between distal regulatory elements have a key role in regulating gene expression, but the extent to which these interactions vary between cell types and contribute to cell-type-specific gene expression remains unclear. Here, to address these questions as part of phase III of the Encyclopedia of DNA Elements (ENCODE), we mapped cohesin-mediated chromatin loops, using chromatin interaction analysis by paired-end tag sequencing (ChIA-PET), and analysed gene expression in 24 diverse human cell types, including core ENCODE cell lines. Twenty-eight per cent of all chromatin loops vary across cell types; these variations modestly correlate with changes in gene expression and are effective at grouping cell types according to their tissue of origin. The connectivity of genes corresponds to different functional classes, with housekeeping genes having few contacts, and dosage-sensitive genes being more connected to enhancer elements. This atlas of chromatin loops complements the diverse maps of regulatory architecture that comprise the ENCODE Encyclopedia, and will help to support emerging analyses of genome structure and function.
has issue date	2020-07-29(xsd:dateTime)
bibo:doi	10.1038/s41586-020-2151-x
bibo:pmid	32728247
has license	cc-by
sha1sum (hex)	931adf73488f9e9174fcac0a04810dcc10fdc563
schema:url	https://doi.org/10.1038/s41586-020-2151-x
resource representing a document's title	Landscape of cohesin-mediated chromatin loops in the human genome
has PubMed Central identifier	PMC7410831
has PubMed identifier	32728247
schema:publication	Nature
resource representing a document's body	covid:931adf73488f9e9174fcac0a04810dcc10fdc563#body_text
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