About: Proteomics analysis of differentially expressed proteins in chicken trachea and kidney after infection with the highly virulent and attenuated coronavirus infectious bronchitis virus in vivo

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About: Proteomics analysis of differentially expressed proteins in chicken trachea and kidney after infection with the highly virulent and attenuated coronavirus infectious bronchitis virus in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Proteomics analysis of differentially expressed proteins in chicken trachea and kidney after infection with the highly virulent and attenuated coronavirus infectious bronchitis virus in vivo
Creator	Han, Zongxi Kong, Xiangang Liu, Shengwang Liu, Xiaoli Shao, Yuhao Sun, Junfeng Cao, Zhongzan Yu, Demin
Source	Medline; PMC
abstract	BACKGROUND: Infectious bronchitis virus (IBV) is first to be discovered coronavirus which is probably endemic in all regions with intensive impact on poultry production. In this study, we used two-dimensional gel electrophoresis (2-DE) and two-dimensional fluorescence difference gel electrophoresis (2-DIGE), coupled with matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF/TOF-MS), to explore the global proteome profiles of trachea and kidney tissues from chicken at different stages infected in vivo with the highly virulent ck/CH/LDL/97I P(5 )strain of infectious bronchitis virus (IBV) and the embryo-passaged, attenuated ck/CH/LDL/97I P(115 )strain. RESULTS: Fifty-eight differentially expressed proteins were identified. Results demonstrated that some proteins which had functions in cytoskeleton organization, anti-oxidative stress, and stress response, showed different change patterns in abundance from chicken infected with the highly virulent ck/CH/LDL/97I P(5 )strain and those given the embryo-passaged, attenuated P(115 )stain. In addition, the dynamic transcriptional alterations of 12 selected proteins were analyzed by the real-time RT-PCR, and western blot analysis confirmed the change in abundance of heat shock proteins (HSP) beta-1, annexin A2, and annexin A5. CONCLUSIONS: The proteomic alterations described here may suggest that these changes to protein expression correlate with IBV virus' virulence in chicken, hence provides valuable insights into the interactions of IBV with its host and may also assist with investigations of the pathogenesis of IBV and other coronavirus infections.
has issue date	2012-03-31(xsd:dateTime)
bibo:doi	10.1186/1477-5956-10-24
bibo:pmid	22463732
has license	cc-by
sha1sum (hex)	9399460a7a75b8ae8a4f5610fd1ecf05d21d2f17
schema:url	https://doi.org/10.1186/1477-5956-10-24
resource representing a document's title	Proteomics analysis of differentially expressed proteins in chicken trachea and kidney after infection with the highly virulent and attenuated coronavirus infectious bronchitis virus in vivo
has PubMed Central identifier	PMC3342233
has PubMed identifier	22463732
schema:publication	Proteome Sci
resource representing a document's body	covid:9399460a7a75b8ae8a4f5610fd1ecf05d21d2f17#body_text
is schema:about of	named entity 'VIRULENT' named entity 'intensive' named entity 'attenuated' named entity 'virulent' named entity 'vivo' named entity 'CHICKEN' named entity 'CORONAVIRUS' named entity 'MATRIX' named entity 'TRACHEA' named entity 'DIFFERENT' named entity 'TOF' named entity 'CHICKEN' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity '282' named entity '115' named entity 'POULTRY PRODUCTION' named entity 'LASER DESORPTION' named entity 'INFECTED' named entity 'TIME-OF-FLIGHT' named entity 'ASSISTED' named entity 'BACKGROUND' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'CORONAVIRUS' named entity 'HIGHLY' named entity 'PROTEINS' named entity 'EXPRESSED' named entity 'PROTEOMICS ANALYSIS' named entity 'INFECTION' named entity 'KIDNEY' named entity 'ATTENUATED' named entity 'TRACHEA' named entity 'IN VIVO' named entity 'PROBABLY' named entity 'REGIONS' named entity 'TANDEM MASS SPECTROMETRY' named entity 'EMBRYO' named entity 'IN VIVO' named entity 'IMPACT' named entity 'KIDNEY' named entity 'DIFFERENCE GEL ELECTROPHORESIS' named entity 'LDL' named entity 'STRAIN' named entity 'TISSUES' named entity 'HIGHLY' named entity 'TWO-DIMENSIONAL GEL ELECTROPHORESIS' named entity 'STAGES' named entity 'STUDY' named entity 'GLOBAL' named entity 'FLUORESCENCE' named entity 'USED' named entity 'VIRULENT' named entity 'PROTEOME' named entity 'ATTENUATED' named entity 'COUPLED' named entity 'ENDEMIC' covid:arg/9399460a7a75b8ae8a4f5610fd1ecf05d21d2f17 named entity 'highly' named entity 'strain' named entity 'virus' named entity 'coronavirus' named entity 'infectious bronchitis' named entity 'trachea' named entity 'Proteomics' named entity 'tandem mass spectrometry' named entity 'fluorescence' named entity 'coronavirus' named entity 'two-dimensional gel electrophoresis' named entity 'IBV' named entity 'LDL' named entity 'Infectious bronchitis virus' named entity 'proteome' named entity 'infection' named entity 'trachea' named entity 'protein'

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