About: Mammalian deltavirus without hepadnavirus coinfection in the neotropical rodent Proechimys semispinosus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Mammalian deltavirus without hepadnavirus coinfection in the neotropical rodent Proechimys semispinosus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mammalian deltavirus without hepadnavirus coinfection in the neotropical rodent Proechimys semispinosus
Creator	Drosten, Christian Muth, Doreen Schroeder, Simon Sommer, Simone Glebe, Dieter Rasche, Andrea Goldmann, Nora Page, Rachel Müller, Marcel Corman, Victor Drexler, Jan Gottula, Lina Jones, Terry Eibner, Georg Heni, Alexander Paraskevopoulou, Sofia Pirzer, Fabian Schmid, Julian
source	Medline; PMC
abstract	Hepatitis delta virus (HDV) is a human hepatitis-causing RNA virus, unrelated to any other taxonomic group of RNA viruses. Its occurrence as a satellite virus of hepatitis B virus (HBV) is a singular case in animal virology for which no consensus evolutionary explanation exists. Here we present a mammalian deltavirus that does not occur in humans, identified in the neotropical rodent species Proechimys semispinosus. The rodent deltavirus is highly distinct, showing a common ancestor with a recently described deltavirus in snakes. Reverse genetics based on a tandem minus-strand complementary DNA genome copy under the control of a cytomegalovirus (CMV) promoter confirms autonomous genome replication in transfected cells, with initiation of replication from the upstream genome copy. In contrast to HDV, a large delta antigen is not expressed and the farnesylation motif critical for HBV interaction is absent from a genome region that might correspond to a hypothetical rodent large delta antigen. Correspondingly, there is no evidence for coinfection with an HBV-related hepadnavirus based on virus detection and serology in any deltavirus-positive animal. No other coinfecting viruses were detected by RNA sequencing studies of 120 wild-caught animals that could serve as a potential helper virus. The presence of virus in blood and pronounced detection in reproductively active males suggest horizontal transmission linked to competitive behavior. Our study establishes a nonhuman, mammalian deltavirus that occurs as a horizontally transmitted infection, is potentially cleared by immune response, is not focused in the liver, and possibly does not require helper virus coinfection.
has issue date	2020-07-28(xsd:dateTime)
bibo:doi	10.1073/pnas.2006750117
bibo:pmid	32651267
has license	cc-by-nc-nd
sha1sum (hex)	93e002e505bc6338cb5d9818366a15e545e451d5
schema:url	https://doi.org/10.1073/pnas.2006750117
resource representing a document's title	Mammalian deltavirus without hepadnavirus coinfection in the neotropical rodent Proechimys semispinosus
has PubMed Central identifier	PMC7395443
has PubMed identifier	32651267
schema:publication	Proc Natl Acad Sci U S A
resource representing a document's body	covid:93e002e505bc6338cb5d9818366a15e545e451d5#body_text
is schema:about of	named entity 'Recent' named entity 'dimers' named entity 'formation' named entity 'Arg' named entity 'replication' named entity 'RNA' named entity 'predicted' named entity 'acid' named entity 'speculated' named entity 'residue' named entity 'DNA-dependent RNA polymerase' named entity 'RNA' named entity 'mRNA' named entity 'ribozyme' named entity 'export' named entity 'essential' named entity 'Cys' named entity 'phosphorylation' named entity 'essential' named entity 'acts' named entity 'ORF' named entity 'HDV' named entity 'located' named entity 'replication' named entity 'RNA' named entity 'domains' named entity 'transport' named entity 'critical' named entity 'incorporating' named entity 'Methylation' named entity 'replication' named entity 'virion' named entity 'acetylation' named entity 'species' named entity 'scheme' named entity 'activating' named entity 'HBV' named entity 'genomic' named entity 'residues' named entity 'replication' named entity 'multimers' named entity 'replication' named entity 'HBV' named entity 'residue' named entity 'multimers' named entity 'Pro' named entity 'nuclear export signal' named entity 'polymerase' named entity 'nucleus' named entity 'DNA-dependent RNA polymerase' named entity 'phosphorylation' named entity 'vertebrate' named entity 'rodent' named entity 'HDV' named entity 'HDV' named entity 'HDV' named entity 'glutamic acid' named entity 'RNA' named entity 'Arg' named entity 'experimental evidence' named entity 'Experimental evidence' named entity 'acetylation' named entity 'HDV' named entity 'HDV'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software