About: Respiratory tract virus infections in the elderly with pneumonia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Respiratory tract virus infections in the elderly with pneumonia
Creator	Söderlund-Venermo, Maria Vuorinen, Tytti Jartti, Tuomas Sadeghi, Mohammadreza Aronen, Matti Hämeenaho, Mira Kohonen, Ia Viikari, Laura Viitanen, Matti Wuorela, Maarit
source	Medline; PMC
abstract	BACKGROUND: In children suffering from severe lower airway illnesses, respiratory virus detection has given good prognostic information, but such reports in the elderly are scarce. Therefore, our aim was to study whether the detection of nasopharyngeal viral pathogens and conventional inflammatory markers in the frail elderly correlate to the presence, signs and symptoms or prognosis of radiographically-verified pneumonia. METHODS: Consecutive episodes of hospital care of patients 65 years and older with respiratory symptoms (N = 382) were prospectively studied as a cohort. Standard clinical questionnaire was filled by the study physician. Laboratory analyses included PCR diagnostics of nasopharyngeal swab samples for 14 respiratory viruses, C-reactive protein (CRP) and white blood cell count (WBC). Chest radiographs were systematically analysed by a study radiologist. The length of hospital stay, hospital revisit and death at ward were used as clinical endpoints. RESULTS: Median age of the patients was 83 years (range 76–90). Pneumonia was diagnosed in 112/382 (29%) of the studied episodes. One or more respiratory viruses were detected in 141/382 (37%) episodes and in 34/112 (30%) episodes also diagnosed with pneumonia. Pneumonia was associated with a WBC over 15 × 10(9)/L (P = .006) and a CRP value over 80 mg/l (P < .05). A virus was detected in 30% of pneumonia episodes and in 40% of non-pneumonia episodes, but this difference was not significant (P = 0.09). The presence of a respiratory virus was associated with fewer revisits to the hospital (P < .05), whereas a CRP value over 100 mg/l was associated with death during hospital stay (P < .05). Respiratory virus detections did not correlate to WBC or CRP values, signs and symptoms or prognosis of radiographically-verified pneumonia episodes. CONCLUSION: Among the elderly with respiratory symptoms, respiratory virus detection was not associated with an increased risk of pneumonia or with a more severe clinical course of the illness. CRP and WBC remain important indicators of pneumonia, and according to our findings, pneumonia should be treated as a bacterial disease regardless of the virus findings. Our data does not support routine virus diagnostics for the elderly patients with pneumonia outside the epidemic seasons. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12877-019-1125-z) contains supplementary material, which is available to authorized users.
has issue date	2019-04-16(xsd:dateTime)
bibo:doi	10.1186/s12877-019-1125-z
bibo:pmid	30991957
has license	cc-by
sha1sum (hex)	94a14012df753e9d47400bf1b660d7559e4976d2
schema:url	https://doi.org/10.1186/s12877-019-1125-z
resource representing a document's title	Respiratory tract virus infections in the elderly with pneumonia
has PubMed Central identifier	PMC6469155
has PubMed identifier	30991957
schema:publication	BMC Geriatr
resource representing a document's body	covid:94a14012df753e9d47400bf1b660d7559e4976d2#body_text
is schema:about of	named entity 'ELDERLY' named entity 'systematically' named entity 'pneumonia' named entity 'The' named entity 'episodes' named entity 'respiratory' named entity 'questionnaire' named entity 'bacterial disease' named entity 'elderly' named entity 'episodes' named entity 'count' named entity 'correlate' named entity 'Conclusion' named entity 'analysed' named entity 'pneumonia' named entity 'PNEUMONIA' covid:arg/94a14012df753e9d47400bf1b660d7559e4976d2 named entity 'HOSPITAL STAY' named entity 'SEVERE CLINICAL COURSE' named entity 'COHORT' named entity 'RESPIRATORY TRACT' named entity 'PROTEIN ' named entity 'VIRUS' named entity 'EPIDEMIC' named entity 'PRESENCE OF' named entity '90%' named entity 'RESPIRATORY VIRUS' named entity 'WARD' named entity 'VIRUS' named entity 'AGE' named entity 'STANDARD' named entity 'SUPPORT' named entity 'DATA' named entity 'BACKGROUND' named entity 'ELDERLY' named entity 'DETECTED' named entity '40%' named entity 'FILLED' named entity 'TREATED' named entity 'RISK OF' named entity 'VALUES' named entity 'PCR' named entity 'BACTERIAL DISEASE' named entity 'INFECTIONS' named entity 'DIAGNOSTICS' named entity 'VIRUS DETECTION' named entity 'OUTSIDE' named entity 'CARE OF' named entity '382' named entity 'BUT' named entity 'NASOPHARYNGEAL' named entity 'LABORATORY' named entity 'C-REACTIVE PROTEIN' named entity 'RESULTS' named entity 'CRP' named entity '30%' named entity 'INCREASED RISK' named entity 'SIGNS AND SYMPTOMS' named entity 'PROGNOSIS' named entity 'DIAGNOSED' named entity 'GOOD' named entity 'ROUTINE' named entity 'PROGNOSTIC' named entity 'CLINICAL' named entity 'CHEST' named entity 'RADIOLOGIST' named entity 'NOT SIGNIFICANT' named entity 'RESPIRATORY VIRUSES' named entity 'INDICATORS' named entity '141' named entity 'HOSPITAL' named entity 'ASSOCIATED WITH'

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