About: Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis
Creator	Franco, Oscar Glisic, Marija Kopp-Heim, Doris Muka, Taulant Peter, · Rojas, Lyda Wolf, · Dante, · Dion Groothof, · Eisenga, F Gómez-Ochoa, Alejandro Hautz, E Jr, Salvador Llanaj, · Michele, · Minder, Beatrice Raguindin, Francis Roa-Díaz, Milena Sergio, · Taneri, Petek Zayne, ·
source	Medline; PMC
abstract	Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and erythrocyte indices) in patients diagnosed with COVID-19, and explored their prognostic value. Six bibliographic databases were searched up to August 3rd 2020. We included 189 unique studies, with data from 57,563 COVID-19 patients. Pooled mean hemoglobin and ferritin levels in COVID-19 patients across all ages were 129.7 g/L (95% Confidence Interval (CI), 128.51; 130.88) and 777.33 ng/mL (95% CI, 701.33; 852.77), respectively. Hemoglobin levels were lower with older age, higher percentage of subjects with diabetes, hypertension and overall comorbidities, and admitted to intensive care. Ferritin level increased with older age, increasing proportion of hypertensive study participants, and increasing proportion of mortality. Compared to moderate cases, severe COVID-19 cases had lower hemoglobin [weighted mean difference (WMD), − 4.08 g/L (95% CI − 5.12; − 3.05)] and red blood cell count [WMD, − 0.16 × 10(12) /L (95% CI − 0.31; − 0.014)], and higher ferritin [WMD, − 473.25 ng/mL (95% CI 382.52; 563.98)] and red cell distribution width [WMD, 1.82% (95% CI 0.10; 3.55)]. A significant difference in mean ferritin levels of 606.37 ng/mL (95% CI 461.86; 750.88) was found between survivors and non-survivors, but not in hemoglobin levels. Future studies should explore the impact of iron metabolism and anemia in the pathophysiology, prognosis, and treatment of COVID-19. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10654-020-00678-5) contains supplementary material, which is available to authorized users.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1007/s10654-020-00678-5
bibo:pmid	32816244
has license	cc-by
sha1sum (hex)	96ff2f59c715728f1b5833729bdc41ea10bd74b0
schema:url	https://doi.org/10.1007/s10654-020-00678-5
resource representing a document's title	Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis
has PubMed Central identifier	PMC7438401
has PubMed identifier	32816244
schema:publication	Eur J Epidemiol
resource representing a document's body	covid:96ff2f59c715728f1b5833729bdc41ea10bd74b0#body_text
is schema:about of	named entity 'WMD' named entity 'systematic review' named entity 'levels' named entity 'prognosis' named entity 'Ferritin' named entity 'impact' named entity 'Iron' named entity 'hypertension' named entity 'hepcidin' named entity 'higher' named entity 'survivors' named entity 'red blood cell' named entity 'proportion' named entity 'transferrin receptor' named entity 'metabolism' named entity 'multiple organ dysfunction syndrome' named entity 'COVID-19' named entity 'patients' named entity 'anemia' named entity 'capacity' named entity 'anemia' named entity 'conducted' named entity 'cases' named entity 'meta-analysis' named entity 'Anemia' named entity 'prognostic' named entity 'hemoglobin' named entity 'COVID-19' named entity 'iron metabolism' named entity 'Coronavirus disease 2019' named entity 'hemoglobin' named entity 'erythrocyte' named entity 'COVID-19' named entity 'intensive care' named entity 'older age' named entity 'Hemoglobin' named entity 'transferrin' named entity 'ferritin' named entity 'hepcidin' named entity 'ferritin' named entity 'iron-binding capacity' named entity 'anemia' named entity 'hemoglobin' named entity 'ng/mL' named entity 'hypertension' named entity 'red blood cell' named entity 'anemia' named entity 'systematic review' named entity 'ARDS' named entity 'ferritin' named entity 'COVID' named entity 'COVID-19' named entity 'COVID' named entity 'follow-up' named entity 'chronic disease' named entity 'ICU' named entity 'ferritin' named entity 'Netherlands' named entity 'anemia' named entity 'ferritin' named entity 'Elsevier'

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