About: The avian influenza virus PA segment mediates strain-specific antagonism of BST-2/tetherin

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About: The avian influenza virus PA segment mediates strain-specific antagonism of BST-2/tetherin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The avian influenza virus PA segment mediates strain-specific antagonism of BST-2/tetherin
Creator	Jongkaewwattana, Anan Teeravechyan, Samaporn Narkpuk, Jaraspim
source	Elsevier; Medline; PMC
abstract	Abstract BST-2 is an antiviral protein described as a powerful cross-species transmission barrier for simian immunodeficiency viruses. Influenza viruses appear to interact with BST-2, raising the possibility that BST-2 may be a barrier for cross-species transmission. An MDCK-based cell line expressing human BST-2 was generated to study human-derived A/Puerto Rico/8/36 (H1N1; PR8) as well as two low pathogenic avian influenza viruses (subtypes H4N6 and H6N1). The H4N6 and H6N1 viruses were less affected by BST-2 expression than PR8, due to their ability to decrease BST-2 levels, a function localized to the PA segment of both avian viruses. Experiments with PA-mutant and -chimeric viruses confirmed that the avian PA segment conferred BST-2 downregulation and antagonism. These results indicate a species-specific ability of PA from low pathogenic avian viruses to mitigate human BST-2 antiviral activity, suggesting that BST-2 is unlikely to be a general cross-species barrier to transmission of such viruses to humans.
has issue date	2018-12-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2018.09.016
bibo:pmid	30290311
has license	els-covid
sha1sum (hex)	97b89d0f8e8cf07adca4b94a09e9cfbe3c9e643f
schema:url	https://doi.org/10.1016/j.virol.2018.09.016
resource representing a document's title	The avian influenza virus PA segment mediates strain-specific antagonism of BST-2/tetherin
has PubMed Central identifier	PMC7172379
has PubMed identifier	30290311
schema:publication	Virology
resource representing a document's body	covid:97b89d0f8e8cf07adca4b94a09e9cfbe3c9e643f#body_text
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