About: Plasmonic silver nanoshells for drug and metabolite detection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Plasmonic silver nanoshells for drug and metabolite detection
Creator	Liu, Yu Li, Yan Zhang, Ru Qian, Kun Chen, Ruoping Huang, Jingyi Huang, Lin Sun, Xuming Vedarethinam, Vadanasundari Wan, Jingjing Wei, Xiang Gurav, Deepanjali
Source	PMC
abstract	In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO(2)@Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics.
has issue date	2017-08-09(xsd:dateTime)
bibo:doi	10.1038/s41467-017-00220-4
bibo:pmid	28790311
has license	cc-by
sha1sum (hex)	9853f82beb2aa6e757484232afa30dba030c50fb
schema:url	https://doi.org/10.1038/s41467-017-00220-4
resource representing a document's title	Plasmonic silver nanoshells for drug and metabolite detection
has PubMed Central identifier	PMC5548796
has PubMed identifier	28790311
schema:publication	Nat Commun
resource representing a document's body	covid:9853f82beb2aa6e757484232afa30dba030c50fb#body_text
is schema:about of	named entity 'brain infection' named entity 'drug detection' named entity 'sheds' named entity 'mirror' named entity 'metabolic' named entity 'drug' named entity 'metabolite' named entity 'DIAGNOSTICS' named entity 'CHALLENGE' named entity 'IN-VITRO' named entity 'DIRECT' named entity 'NEEDS' named entity 'CONSTRUCT' named entity 'DISEASE DIAGNOSIS' named entity 'MASS SPECTROMETRY' named entity 'IN BLOOD' named entity 'CLINICAL PRACTICE' named entity 'OUR' named entity 'SILVER' named entity 'SAMPLE PREPARATION' named entity 'CEREBROSPINAL FLUID' named entity 'IDENTIFIED' named entity 'LASER DESORPTION' named entity 'VALIDATED' named entity 'DESIGN' named entity 'BIOMEDICAL RESEARCH' named entity 'MOLECULAR' named entity 'DUE TO' named entity 'SYNTHESIZED' named entity 'PLATFORM' named entity 'WORK' named entity 'ADVANCED' named entity 'THERAPEUTIC EVALUATION' named entity 'PHARMACOKINETICS' named entity 'IN CEREBROSPINAL FLUID' named entity 'PATIENTS' named entity 'BASED' named entity 'ABUNDANCE' named entity 'MULTI' named entity 'POSTOPERATIVE' named entity 'FLUIDS' named entity 'USED' named entity 'NANOSHELLS' named entity 'DETECTION' named entity 'DRUG' named entity 'METABOLITE' named entity 'SILVER' named entity 'MIRROR' named entity '0.5' named entity 'THESE' named entity 'FUNCTION' named entity 'SAMPLES' named entity 'SAMPLE' named entity 'QUANTITATION' named entity 'DIAGNOSTIC' named entity 'METABOLITE' named entity 'NANOSHELLS' named entity 'SYSTEMS' named entity 'MATERIALS' named entity 'LOW' named entity 'REACTIONS' named entity 'TOOLS' named entity 'LIGHT' named entity 'COMPLEXITY' named entity 'DAILY' named entity 'BRAIN' named entity 'MONITORING' named entity 'USING' named entity 'MEASURED' named entity 'INFECTION'

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