About: Concentration-dependent mortality of chloroquine in overdose

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Concentration-dependent mortality of chloroquine in overdose
Creator	White, Nicholas Tarning, Joel Watson, James Baud, Frederic Clemessy, Jean-Luc Hoglund, Richard Megarbane, Bruno
source	Medline; PMC
abstract	Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment. Although generally safe they are potentially lethal in overdose. In-vitro data suggest that high concentrations and thus high doses are needed for COVID-19 infections, but as yet there is no convincing evidence of clinical efficacy. Bayesian regression models were fitted to survival outcomes and electrocardiograph QRS durations from 302 prospectively studied French patients who had taken intentional chloroquine overdoses, of whom 33 died (11%), and 16 healthy volunteers who took 620 mg base chloroquine single doses. Whole blood concentrations of 13.5 µmol/L (95% credible interval 10.1–17.7) were associated with 1% mortality. Prolongation of ventricular depolarization is concentration-dependent with a QRS duration >150 msec independently highly predictive of mortality in chloroquine self-poisoning. Pharmacokinetic modeling predicts that most high dose regimens trialled in COVID-19 are unlikely to cause serious cardiovascular toxicity.
has issue date	2020-07-08(xsd:dateTime)
bibo:doi	10.7554/elife.58631
bibo:pmid	32639233
has license	cc-by
sha1sum (hex)	98593a87a1e0b0589b7bcff048ecfdb08d83e822
schema:url	https://doi.org/10.7554/elife.58631
resource representing a document's title	Concentration-dependent mortality of chloroquine in overdose
has PubMed Central identifier	PMC7417172
has PubMed identifier	32639233
schema:publication	eLife
resource representing a document's body	covid:98593a87a1e0b0589b7bcff048ecfdb08d83e822#body_text
is schema:about of	named entity 'fitted' named entity 'Hydroxychloroquine' named entity 'intentional' named entity 'efficacy' named entity 'chloroquine' named entity 'ventricular' named entity 'chloroquine' named entity 'DIED' named entity 'FITTED' named entity 'SELF-POISONING' named entity 'COVID-19' named entity 'FRENCH' named entity 'SAFE' named entity 'survival' named entity 'high' named entity 'high' named entity 'Prolongation' named entity 'high' named entity 'dose' named entity 'independently' named entity 'models' named entity 'infections' named entity 'Although' named entity 'In-vitro' named entity 'Pharmacokinetic' named entity 'COVID-19' named entity 'Bayesian regression' named entity 'malaria' named entity 'hydroxychloroquine' named entity 'sickle cell disease' named entity 'posterior distributions' named entity 'pharmacodynamic' named entity 'Chloroquine' named entity 'oral administration' named entity 'chloroquine' named entity 'chloroquine' named entity 'chloroquine' named entity 'vomiting' named entity 'hydroxychloroquine' named entity 'msec' named entity 'long term' named entity 'Bourré' named entity 'letrozole' named entity 'blood transfusion' named entity 'chloroquine' named entity 'chloroquine' named entity 'oxygen' named entity 'regression model' named entity 'self-poisoning' named entity 'depolarization' named entity 'plasma' named entity 'rheumatological' named entity 'Health Commission' named entity 'pharmacokinetic' named entity 'iatrogenic' named entity 'metabolite' named entity 'concentration measurements' named entity 'COVID-19' named entity 'chloroquine' named entity 'logistic regression' named entity 'spectrophotometry' named entity 'msec' named entity 'torsade de pointes' named entity 'intensive care' named entity 'chloroquine' named entity 'cardiac toxicity' named entity 'chloroquine' named entity 'Allometric scaling' named entity 'metabolite' named entity 'QT prolongation' named entity 'overdose' named entity 'toxicity' named entity 'heteroskedasticity' named entity 'long term' named entity 'leukocytes'

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