About: Polyploidy in the adult Drosophila brain

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Polyploidy in the adult Drosophila brain
Creator	Buttitta, Laura Grushko, Olga Nandakumar, Shyama
Source	PMC
abstract	Long-lived cells such as terminally differentiated postmitotic neurons and glia must cope with the accumulation of damage over the course of an animal’s lifespan. How long-lived cells deal with ageing-related damage is poorly understood. Here we show that polyploid cells accumulate in the adult fly brain and that polyploidy protects against DNA damage-induced cell death. Multiple types of neurons and glia that are diploid at eclosion, become polyploid in the adult Drosophila brain. The optic lobes exhibit the highest levels of polyploidy, associated with an elevated DNA damage response in this brain region. Inducing oxidative stress or exogenous DNA damage leads to an earlier onset of polyploidy, and polyploid cells in the adult brain are more resistant to DNA damage-induced cell death than diploid cells. Our results suggest polyploidy may serve a protective role for neurons and glia in adult Drosophila melanogaster brains.
has issue date	2020-08-25(xsd:dateTime)
bibo:doi	10.7554/elife.54385
bibo:pmid	32840209
has license	cc-by
sha1sum (hex)	986f9b1742bffef83795a5fb9279f5f5d98f1d8a
schema:url	https://doi.org/10.7554/elife.54385
resource representing a document's title	Polyploidy in the adult Drosophila brain
has PubMed Central identifier	PMC7447450
has PubMed identifier	32840209
resource representing a document's body	covid:986f9b1742bffef83795a5fb9279f5f5d98f1d8a#body_text
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