About: Molecular typing of a novel canine parvovirus type 2a mutant circulating in Italy

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About: Molecular typing of a novel canine parvovirus type 2a mutant circulating in Italy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular typing of a novel canine parvovirus type 2a mutant circulating in Italy
Creator	Decaro, Nicola Dowgier, Giulia Di Bella, Santina Gucciardi, Francesca Guercio, Annalisa Macaluso, Giusi Mira, Francesco Purpari, Giuseppa Randazzo, Vincenzo Vicari, Domenico
source	Elsevier; Medline; PMC
abstract	Abstract Canine parvovirus (CPV) is the etiological agent of a severe viral disease of dogs. After its emergence in late 1970s, the CPV original type (CPV-2) was rapidly and totally replaced by three antigenic variants named CPV-2a, CPV-2b and CPV-2c. CPV has an evolutionary rate nearest to those of RNA viruses, with consequences on disease diagnosis and epidemiology. This paper reports the molecular characterization of eight CPV-2a strains collected from dogs in Italy in 2016–2017. Genetic analysis was conducted on a CPV genomic region encompassing both open reading frames (ORFs) encoding for nonstructural (NS1-NS2) and structural proteins (VP1-VP2). Sequence analysis indicates new and unreported sequence changes, mainly affecting the VP2 gene, which included the mutation Tyr324Leu. This study represents the first evidence of a new CPV-2a mutant (VP2 324Leu) and illustrates the importance of a continuous molecular survey in order to obtain more information on effective spread of new CPV mutants.
has issue date	2018-07-31(xsd:dateTime)
bibo:doi	10.1016/j.meegid.2018.03.010
bibo:pmid	29548803
has license	els-covid
sha1sum (hex)	989c34b373a88768c74cff26bb57ca36c6ba415b
schema:url	https://doi.org/10.1016/j.meegid.2018.03.010
resource representing a document's title	Molecular typing of a novel canine parvovirus type 2a mutant circulating in Italy
has PubMed Central identifier	PMC7185394
has PubMed identifier	29548803
schema:publication	Infection, Genetics and Evolution
resource representing a document's body	covid:989c34b373a88768c74cff26bb57ca36c6ba415b#body_text
is schema:about of	named entity 'NOVEL' named entity 'type' named entity 'structural proteins' named entity 'survey' named entity 'MOLECULAR' named entity 'VARIANTS' named entity 'GENETIC ANALYSIS' named entity 'NEAREST' named entity 'AGENT' named entity 'REGION' named entity 'EVOLUTIONARY RATE' named entity 'SEQUENCE' named entity 'CHANGES' named entity 'CONTINUOUS' named entity 'ORIGINAL' named entity 'CHARACTERIZATION' named entity 'DOGS' named entity 'STUDY' named entity 'CANINE PARVOVIRUS' named entity 'CANINE PARVOVIRUS' named entity 'MUTATION' named entity 'REPLACED BY' named entity 'TYPE' named entity 'STRUCTURAL PROTEINS' named entity 'VIRAL DISEASE' named entity 'EFFECTIVE' named entity 'ITALY' named entity 'MUTANT' named entity 'CIRCULATING' named entity 'MOLECULAR TYPING' named entity 'SEQUENCE ANALYSIS' named entity 'GENE' named entity 'REPORTS' named entity 'INCLUDED' named entity 'LATE' named entity 'RNA VIRUSES' named entity 'SEVERE' named entity 'NAMED' named entity 'NS2' named entity 'ORDER' named entity 'AFFECTING' named entity 'OPEN READING FRAMES' named entity 'DISEASE DIAGNOSIS' named entity 'INFORMATION' named entity 'GENOMIC' named entity 'MUTANT' named entity 'RAPIDLY' named entity 'EPIDEMIOLOGY' named entity 'TYPE' named entity 'CPV' named entity 'SPREAD' named entity 'OBTAIN' named entity 'SURVEY' named entity 'VP2' named entity 'ITS' named entity 'COLLECTED' named entity 'ITALY' named entity 'EMERGENCE' named entity 'ENCODING' named entity 'STRAINS' named entity 'NEW' named entity 'PAPER' named entity 'TOTALLY' named entity 'EVIDENCE OF' named entity 'CONSEQUENCES' named entity 'strains' named entity 'After' named entity 'genome' named entity 'genus' named entity 'VP2' named entity 'Italian' named entity 'molecule'

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