About: Genetic Diversity and Differentiation at Structurally Varying MHC Haplotypes and Microsatellites in Bottlenecked Populations of Endangered Crested Ibis

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About: Genetic Diversity and Differentiation at Structurally Varying MHC Haplotypes and Microsatellites in Bottlenecked Populations of Endangered Crested Ibis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genetic Diversity and Differentiation at Structurally Varying MHC Haplotypes and Microsatellites in Bottlenecked Populations of Endangered Crested Ibis
Creator	Zhou, Tong Fang, Sheng-Guo Lan, Hong Wan, Qiu-Hong
source	PMC
abstract	Investigating adaptive potential and understanding the relative roles of selection and genetic drift in populations of endangered species are essential in conservation. Major histocompatibility complex (MHC) genes characterized by spectacular polymorphism and fitness association have become valuable adaptive markers. Herein we investigate the variation of all MHC class I and II genes across seven populations of an endangered bird, the crested ibis, of which all current individuals are offspring of only two pairs. We inferred seven multilocus haplotypes from linked alleles in the Core Region and revealed structural variation of the class II region that probably evolved through unequal crossing over. Based on the low polymorphism, structural variation, strong linkage, and extensive shared alleles, we applied the MHC haplotypes in population analysis. The genetic variation and population structure at MHC haplotypes are generally concordant with those expected from microsatellites, underlining the predominant role of genetic drift in shaping MHC variation in the bottlenecked populations. Nonetheless, some populations showed elevated differentiation at MHC, probably due to limited gene flow. The seven populations were significantly differentiated into three groups and some groups exhibited genetic monomorphism, which can be attributed to founder effects. We therefore propose various strategies for future conservation and management.
has issue date	2019-04-25(xsd:dateTime)
bibo:doi	10.3390/cells8040377
bibo:pmid	31027280
has license	cc-by
sha1sum (hex)	98e6190d06a8d8774c690be39634a1d64a926dc3
schema:url	https://doi.org/10.3390/cells8040377
resource representing a document's title	Genetic Diversity and Differentiation at Structurally Varying MHC Haplotypes and Microsatellites in Bottlenecked Populations of Endangered Crested Ibis
has PubMed Central identifier	PMC6523929
has PubMed identifier	31027280
schema:publication	Cells
resource representing a document's body	covid:98e6190d06a8d8774c690be39634a1d64a926dc3#body_text
is schema:about of	named entity 'strong' named entity 'shared' named entity 'extensive' named entity 'CRESTED IBIS' named entity 'GROUPS' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX' named entity 'STRATEGIES' named entity 'FUTURE' named entity 'ALLELES' named entity 'SHARED' named entity 'ROLE' named entity 'RELATIVE' named entity 'GENE FLOW' named entity 'GENETIC DRIFT' named entity 'APPLIED' named entity 'CLASS II' named entity 'ENDANGERED' named entity 'INVESTIGATING' named entity 'PROBABLY' named entity 'SELECTION' named entity 'ENDANGERED SPECIES' named entity 'MHC CLASS I' named entity 'REVEALED' named entity 'ASSOCIATION' named entity 'DIFFERENTIATED' named entity 'POLYMORPHISM' named entity 'SHAPING' named entity 'GENERALLY' named entity 'ELEVATED' named entity 'POPULATIONS' named entity 'EVOLVED' named entity 'ADAPTIVE' named entity 'SEVEN' named entity 'CHARACTERIZED' named entity 'INDIVIDUALS' named entity 'CONSERVATION' named entity 'LINKAGE' named entity 'MHC' named entity 'MICROSATELLITES' named entity 'LIMITED' named entity 'FOUNDER EFFECTS' named entity 'CROSSING OVER' named entity 'VARIATION' named entity 'CORE REGION' named entity 'ENDANGERED' named entity 'INVESTIGATE' named entity 'GENETIC' named entity 'FITNESS' named entity 'POPULATION ANALYSIS' named entity 'MHC' named entity 'HAPLOTYPES' named entity 'CURRENT' named entity 'STRUCTURAL VARIATION' named entity 'POPULATION STRUCTURE' named entity 'GENETIC DIVERSITY' named entity 'DIFFERENTIATION' named entity 'VARYING' named entity 'POPULATIONS' named entity 'MICROSATELLITES' named entity 'UNDERLINING' named entity 'UNEQUAL' named entity 'ESSENTIAL' named entity 'BASED' named entity 'PREDOMINANT' named entity 'MANAGEMENT' named entity 'EXPECTED' named entity 'OFFSPRING' named entity 'HAVE' named entity 'MARKERS' named entity 'HAPLOTYPES' named entity 'EXTENSIVE' named entity 'ROLES' named entity 'DUE TO' named entity 'DIFFERENTIATION' named entity 'GENETIC VARIATION' named entity 'BIRD' named entity 'MULTILOCUS' named entity 'VARIOUS'

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