About: Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation
Creator	Daumas, Stephanie Djibo, Mahamadou Erickson, Jeffrey Pietrancosta, Nicolas Mestikawy, Salah
Source	PMC
abstract	Vesicular glutamate transporters (VGLUTs) control quantal size of glutamatergic transmission and have been the center of numerous studies over the past two decades. VGLUTs contain two independent transport modes that facilitate glutamate packaging into synaptic vesicles and phosphate (Pi) ion transport into the synaptic terminal. While a transmembrane proton electrical gradient established by a vacuolar-type ATPase powers vesicular glutamate transport, recent studies indicate that binding sites and flux properties for chloride, potassium, and protons within VGLUTs themselves regulate VGLUT activity as well. These intrinsic ionic binding and flux properties of VGLUTs can therefore be modulated by neurophysiological conditions to affect levels of glutamate available for release from synapses. Despite their extraordinary importance, specific and high-affinity pharmacological compounds that interact with these sites and regulate VGLUT function, distinguish between the various modes of transport, and the different isoforms themselves, are lacking. In this review, we provide an overview of the physiologic sites for VGLUT regulation that could modulate glutamate release in an over-active synapse or in a disease state.
has issue date	2020-05-30(xsd:dateTime)
bibo:doi	10.1007/s12035-020-01912-7
has license	no-cc
sha1sum (hex)	9a5abf8de16575678e3443f8df43fbc311d1fd98
schema:url	https://doi.org/10.1007/s12035-020-01912-7
resource representing a document's title	Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation
has PubMed Central identifier	PMC7261050
schema:publication	Mol Neurobiol
resource representing a document's body	covid:9a5abf8de16575678e3443f8df43fbc311d1fd98#body_text
is schema:about of	named entity 'regulation' named entity 'synapse' named entity 'While' named entity 'vesicular' named entity 'flux' named entity 'INTERACT' named entity 'ION TRANSPORT' named entity 'TRANSMEMBRANE' named entity 'release' named entity 'glutamate' named entity 'control' named entity 'size' named entity 'glutamate' named entity 'protons' named entity 'pharmacological' named entity 'chloride' named entity 'Pharmacological' named entity 'Sites' named entity 'flux' named entity 'isoforms' named entity 'chloride' named entity 'phosphate' named entity 'quantal' named entity 'potassium' named entity 'neurophysiological' named entity 'glutamatergic' named entity 'binding sites' named entity 'glutamate' named entity 'ion transport' named entity 'Vesicular Glutamate Transporter' named entity 'powers' named entity 'glutamate' named entity 'altered expression' named entity 'VGLUT3' named entity 'post-synaptic' named entity 'lactone' named entity 'VGLUTs' named entity 'protein' named entity 'GABA' named entity 'ATPase' named entity 'VGLUTs' named entity 'vesicles' named entity 'ACPD' named entity 'presynaptic terminals' named entity 'VGLUT' named entity 'glutamate' named entity 'biophysically' named entity 'neurons' named entity 'ion gradients' named entity 'VMAT2' named entity 'Rose Bengal' named entity 'status epilepticus' named entity 'isoforms' named entity 'VGLUT' named entity 'cerebellar' named entity 'vesicles' named entity 'methyl valerate' named entity 'VGLUTs' named entity 'VGLUT2' named entity 'extracellular' named entity 'VGLUT' named entity 'glutamate' named entity 'synapses' named entity 'neurotransmitter transporters' named entity 'glutamate' named entity 'vesicles' named entity 'chloride' named entity 'neurons' named entity 'glutamatergic' named entity 'vesicular GABA transporter' named entity 'glutamate' named entity 'glutamate' named entity 'synaptic terminals' named entity 'excitotoxicity' named entity 'VGLUTs' named entity 'ischemic' named entity 'synapses' named entity 'Glutamate' named entity 'binding sites'

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