About: MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity

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About: MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity
Creator	Atway, Rayann Capaldo, Brian Carrabba, Nicole Gryder, Berkley Lake, Ross Sowalsky, Adam Terrigino, Nicholas Thomas Hennigan, S Trostel, Shana Walton, Elizabeth Whitlock, Nichelle Wilkinson, Scott Ye, Huihui
Source	BioRxiv
abstract	Localized prostate cancer develops very slowly in most men, with the androgen receptor (AR) and MYC transcription factors amongst the most well-characterized drivers of prostate tumorigenesis. Canonically, MYC up-regulation in luminal prostate cancer cells functions to oppose the terminally differentiating effects of AR. However, the effects of MYC up-regulation are pleiotropic and inconsistent with a poorly proliferative phenotype. Here we show that increased MYC expression and activity are associated with the down-regulation of MEIS1, a HOX-family transcription factor. Using RNA-seq to profile a series of human prostate cancer specimens laser capture microdissected on the basis of MYC immunohistochemistry, MYC activity and MEIS1 expression were inversely correlated. Knockdown of MYC expression in prostate cancer cells increased expression of MEIS1 and increased occupancy of MYC at the MEIS1 locus. Finally, we show in laser capture microdissected human prostate cancer samples and the prostate TCGA cohort that MEIS1 expression is inversely proportional to AR activity as well as HOXB13, a known interacting protein of both AR and MEIS1. Collectively, our data demonstrate that elevated MYC in a subset of primary prostate cancers functions in a negative role in regulating MEIS1 expression, and that this down-regulation may contribute to MYC-driven development and progression.
has issue date	2019-11-20(xsd:dateTime)
bibo:doi	10.1101/848952
has license	biorxiv
sha1sum (hex)	9a6cc4dd6b342a2a6ebbf5bd003c757fb7b40720
schema:url	https://doi.org/10.1101/848952
resource representing a document's title	MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity
schema:publication	bioRxiv
resource representing a document's body	covid:9a6cc4dd6b342a2a6ebbf5bd003c757fb7b40720#body_text
is schema:about of	named entity 'MYC' named entity 'secondary antibody' named entity 'FASTQ' named entity 'MYC' named entity 'RNA' named entity 'MYC' named entity 'MYC' named entity 'Bio-Rad' named entity 'differentially expressed genes' named entity 'MYC' named entity 'oncogene' named entity 'HOXB13' named entity 'MYC' named entity 'TCGA' named entity 'tumor' named entity 'pathogenesis' named entity 'MYC' named entity 'positive correlation' named entity 'HOXB13' named entity 'statistical significance' named entity 'stroma' named entity 'MYC' named entity 'conjugated' named entity 'RNAseq' named entity 'hCMV' named entity 'biological functions' named entity 'RNA-seq' named entity 'tumor' named entity 'MYC' named entity 'nuclei' named entity 'primary tumors' named entity 'shRNA' named entity 'MYC' named entity 'Ki67' named entity 'MYC' named entity 'photomicrograph' named entity 'MYC' named entity 'Antibody' named entity 'phenotypes' named entity 'Burkitt's' named entity 'cancer precursor' named entity 'MEIS1' named entity 'Q30' named entity 'MYC' named entity 'negatively correlated' named entity 'MYC' named entity 'MYC' named entity 'LNCaP' named entity 'GAPDH' named entity 'HOXB13' named entity 'transcription' named entity 'MYC' named entity 'Dharmacon' named entity 'differentially expressed genes' named entity 'RNA' named entity 'phenotype' named entity 'lymphocytes' named entity 'MYC' named entity 'prostate cancer cells' named entity 'gene set enrichment analysis' named entity 'tumors' named entity 'prostate cancer' named entity 'ribosomal biogenesis' named entity 'MYC' named entity 'transcriptome' named entity 'Definiens' named entity 'Nucleus' named entity 'MYC' named entity 'LNCaP' named entity 'MYC' named entity 'MEIS1' named entity 'co-factors'

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