About: Confounding roles for type I interferons during bacterial and viral pathogenesis

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About: Confounding roles for type I interferons during bacterial and viral pathogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Confounding roles for type I interferons during bacterial and viral pathogenesis
Creator	Carrero, Javier
Source	PMC
abstract	Although type I interferons (IFN-I) were initially defined as potent antiviral agents, they can also cause decreased host resistance to some bacterial and viral infections. The many antiviral functions of the IFN-I include direct suppression of viral replication and activation of the immune response against viruses. In addition to their antiviral effects, IFN-I are also protective against several extracellular bacterial infections, in part, by promoting the induction of TNF-α and nitric oxide. In contrast, there is a negative effect of IFN-I on host resistance during chronic infection with lymphocytic choriomeningitis virus (LCMV) and acute infections with intracellular bacteria. In the case of LCMV, chronic IFN-I signaling induces adaptive immune system suppression. Blockade of IFN-I signaling removes the suppression and allows CD4 T-cell- and IFN-γ-mediated resolution of the infection. During acute intracellular bacterial infection, IFN-I suppress innate immunity by at least two defined mechanisms. During Francisella infection, IFN-I prevent IL-17 upregulation on γδ T cells and neutrophil recruitment. Following Listeria infection, IFN-I promote the cell death of macrophages and lymphocytes, which leads to innate immune suppression. These divergent findings for the role of IFN-I on pathogen control emphasize the complexity of the interferons system and force more mechanistic evaluation of its role in pathogenesis. This review evaluates IFN-I during infection with an emphasis on work carried out IFN-I-receptor-deficient mice.
has issue date	2013-10-24(xsd:dateTime)
bibo:doi	10.1093/intimm/dxt050
bibo:pmid	24158954
has license	bronze-oa
sha1sum (hex)	9af080e7508ef52bd7c9b68cf0bd6136d8ca2c3d
schema:url	https://doi.org/10.1093/intimm/dxt050
resource representing a document's title	Confounding roles for type I interferons during bacterial and viral pathogenesis
has PubMed Central identifier	PMC3839063
has PubMed identifier	24158954
schema:publication	International Immunology
resource representing a document's body	covid:9af080e7508ef52bd7c9b68cf0bd6136d8ca2c3d#body_text
is schema:about of	named entity 'Confounding' named entity 'REVIEW' named entity 'RECEPTOR' named entity 'LEADS' named entity 'IFN' named entity 'FORCE' named entity 'ROLE' named entity 'EVALUATION' named entity 'WORK' named entity 'BACTERIAL' named entity 'SYSTEM' named entity 'ITS' named entity 'INTERFERONS' named entity 'TYPE I INTERFERONS' named entity 'IMMUNE SUPPRESSION' named entity 'FINDINGS' named entity 'VIRAL PATHOGENESIS' named entity 'LYMPHOCYTES' named entity 'ROLES' named entity 'THESE' named entity 'CARRIED' named entity 'MICE' named entity 'DEFICIENT' named entity 'COMPLEXITY' named entity 'PATHOGEN CONTROL' named entity 'INFECTION' named entity 'PATHOGENESIS' named entity 'mice' named entity 'emphasize' named entity 'IFN' named entity 'infection' named entity 'type I interferons' named entity 'Confounding' named entity 'IFNAR2' named entity 'pore-forming toxin' named entity 'viral infections' named entity 'physiological' named entity 'IFN-γ' named entity 'IFNGR' named entity 'Francisella' named entity 'IFNAR' named entity 'Molecular cloning' named entity 'lymphocytic choriomeningitis virus' named entity 'c-di-AMP' named entity 'type II interferon' named entity 'interferons' named entity 'interferons' named entity 'IFNAR' named entity 'IFN' named entity 'T-cell' named entity 'Salmonella' named entity 'IFNLR1' named entity 'lymphocyte' named entity 'γδ T cells' named entity 'infection' named entity 'viruses' named entity 'IL-10' named entity 'cytosol' named entity 'mice' named entity 'lymphocytes' named entity 'IFN-I receptor' named entity 'Dendritic cells' named entity 'apoptosis' named entity 'IFN' named entity 'agonists' named entity 'MyD88' named entity 'antiviral activity' named entity 'IFN-β' named entity 'DCs' named entity 'T-cell' named entity 'signaling pathways' named entity 'IFN-γ' named entity 'interferons' named entity 'interferons' named entity 'negative regulator' named entity 'infection' named entity 'bacterial infection' named entity 'viral replication' named entity 'bacterial infection' named entity 'viral infection' named entity 'C57BL/6'

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