About: Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation

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About: Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation
Creator	Miesbach, W Asherson, Ae Scharrer, Ae
topic	covid:9b5295e562402c170f5f51adb00194c5bfde9af5#this
source	PMC
abstract	We report on a 32-year old female patient with primary antiphospholipid syndrome (PAPS) and several thromboembolic events despite stable doses of oral anticoagulation, good patient compliance and maintained INR values of >3. Over the preceding 3 years the patient had presented a wide spectrum of manifestations of APS, including recurrent venous and arterial thromboses, cardiac, gynecological (HELLP syndrome), neurological involvements, livedo reticularis, a mild thrombocytopenia and the most feared manifestation of the catastrophic antiphospholipid syndrome (CAPS). Life-threatening bilateral subdural bleeding occurred while she was anticoagulated. The clinical features appeared to be refractory to oral anticoagulation with phenprocoumon. They were life threatening on each occasion and she developed repetitive episodes of organ damage with cardiac insufficiency (NYHA III), pulmonary hypertension and other residual defects. Even during heparinization recurrent thromboembolism supervened as well as livedo reticularis of the extremities. Lupus anticoagulants (LAC), anticardiolipin (aCL) antibodies and anti-β(2)-glycoprotein-1 (β(2)GPI) titers were all markedly elevated. This case report shows that recurrent episodes of thrombosis can occur despite seemingly adequate anticoagulation in patients with CAPS.
has issue date	2004-03-20(xsd:dateTime)
bibo:doi	10.1007/s10067-004-0864-0
bibo:pmid	15168158
has license	no-cc
sha1sum (hex)	9b5295e562402c170f5f51adb00194c5bfde9af5
schema:url	https://doi.org/10.1007/s10067-004-0864-0
resource representing a document's title	Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation
has PubMed Central identifier	PMC7102000
has PubMed identifier	15168158
schema:publication	Clin Rheumatol
resource representing a document's body	covid:9b5295e562402c170f5f51adb00194c5bfde9af5#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/9b5295e562402c170f5f51adb00194c5bfde9af5
is schema:about of	named entity 'extremities' named entity 'arterial' named entity 'patients' named entity 'patient compliance' named entity 'cardiac insufficiency' named entity 'CASE' named entity 'ANTIBODIES' named entity 'NEUROLOGICAL' named entity 'PRECEDING' named entity 'LIFE' named entity 'SYNDROME' named entity 'INCLUDING' named entity 'ORAL ANTICOAGULATION' named entity 'CARDIAC INSUFFICIENCY' named entity 'MARKEDLY' named entity 'REPORT' named entity 'INR' named entity 'APS' named entity 'THROMBOEMBOLIC EVENTS' named entity 'anticoagulated' named entity 'thromboembolism' named entity 'NYHA' named entity 'aCL' named entity 'venous' named entity 'life' named entity 'maintained' named entity 'patient' named entity 'patient' named entity 'anticoagulants' named entity 'case report' named entity 'thrombosis' named entity 'thrombocytopenia' named entity 'phenprocoumon' named entity 'patient compliance' named entity 'anticoagulation' named entity 'anticoagulation' named entity 'thromboembolism' named entity 'primary' named entity 'myocardial infarction' named entity 'neurologic' named entity 'antibodies' named entity 'anticoagulation' named entity 'abdomen' named entity 'craniotomy' named entity 'subdural hematoma' named entity 'glycoprotein' named entity 'thrombin time' named entity 'pregnancy' named entity 'coronary embolism' named entity 'Electromyography' named entity 'platelets' named entity 'embolus' named entity 'intravenous' named entity 'spiral CT scan' named entity 'clotting time' named entity 'chest pain' named entity 'pulmonary embolism' named entity 'thromboses' named entity 'major bleeding' named entity 'anticoagulation' named entity 'Retrospective studies' named entity 'activated protein C resistance' named entity 'coronary artery disease' named entity 'systemic lupus erythematosus' named entity 'plasma' named entity 'anticoagulation' named entity 'antibodies' named entity 'anticoagulants' named entity 'autoantibodies' named entity 'international normalized ratio' named entity 'Sepsis' named entity 'AST and ALT' named entity 'loss of sensitivity' named entity 'occlusions' named entity 'pulmonary emboli' named entity 'ultrasound scan' named entity 'CT scan'

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