About: Function, Architecture, and Biogenesis of Reovirus Replication Neoorganelles

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About: Function, Architecture, and Biogenesis of Reovirus Replication Neoorganelles Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Function, Architecture, and Biogenesis of Reovirus Replication Neoorganelles
Creator	Risco, Cristina Tenorio, Raquel Dermody, Terence Fernández De Castro, Isabel Knowlton, Jonathan Sutherland, Danica Zamora, Paula
topic	covid:9be40fd878c72fc18e2557ccc3cc8b4ef95a926d#this
Source	Medline; PMC
abstract	Most viruses that replicate in the cytoplasm of host cells form neoorganelles that serve as sites of viral genome replication and particle assembly. These highly specialized structures concentrate viral proteins and nucleic acids, prevent the activation of cell-intrinsic defenses, and coordinate the release of progeny particles. Reoviruses are common pathogens of mammals that have been linked to celiac disease and show promise for oncolytic applications. These viruses form nonenveloped, double-shelled virions that contain ten segments of double-stranded RNA. Replication organelles in reovirus-infected cells are nucleated by viral nonstructural proteins µNS and σNS. Both proteins partition the endoplasmic reticulum to form the matrix of these structures. The resultant membranous webs likely serve to anchor viral RNA–protein complexes for the replication of the reovirus genome and the assembly of progeny virions. Ongoing studies of reovirus replication organelles will advance our knowledge about the strategies used by viruses to commandeer host biosynthetic pathways and may expose new targets for therapeutic intervention against diverse families of pathogenic viruses.
has issue date	2019-03-21(xsd:dateTime)
bibo:doi	10.3390/v11030288
bibo:pmid	30901959
has license	cc-by
sha1sum (hex)	9be40fd878c72fc18e2557ccc3cc8b4ef95a926d
schema:url	https://doi.org/10.3390/v11030288
resource representing a document's title	Function, Architecture, and Biogenesis of Reovirus Replication Neoorganelles
has PubMed Central identifier	PMC6466366
has PubMed identifier	30901959
schema:publication	Viruses
resource representing a document's body	covid:9be40fd878c72fc18e2557ccc3cc8b4ef95a926d#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/9be40fd878c72fc18e2557ccc3cc8b4ef95a926d
is schema:about of	named entity 'organelles' named entity 'viruses' named entity 'commandeer' named entity 'proteins' named entity 'Reovirus' named entity 'viruses' named entity 'VIRAL NONSTRUCTURAL PROTEINS' named entity 'MAMMALS' named entity 'COMMON' named entity 'MEMBRANOUS' named entity 'NUCLEIC ACIDS' named entity 'PARTICLE' named entity 'WEBS' named entity 'LIKELY' named entity 'PROMISE' named entity 'INFECTED' named entity 'DOUBLE-STRANDED RNA' named entity 'RELEASE' named entity 'ANCHOR' named entity 'PROGENY' named entity 'PATHOGENIC' named entity 'PREVENT' named entity 'ONCOLYTIC' named entity 'ENDOPLASMIC RETICULUM' named entity 'PROTEINS' named entity 'ORGANELLES' named entity 'VIRAL GENOME REPLICATION ' named entity 'REOVIRUS' named entity 'CONTAIN' named entity 'TARGETS' named entity 'THESE' named entity 'THERAPEUTIC INTERVENTION' named entity 'STUDIES' named entity 'EXPOSE' named entity 'VIRIONS' named entity 'SPECIALIZED' named entity 'CELL' named entity 'PATHOGENS' named entity 'NEW' named entity 'MATRIX' named entity 'SERVE' named entity 'USED BY' named entity 'BIOSYNTHETIC PATHWAYS' named entity 'GENOME' named entity 'FUNCTION' named entity 'REPLICATION' named entity 'SEGMENTS' named entity 'CELIAC DISEASE' named entity 'DIVERSE' named entity 'PARTITION' named entity 'HOST CELLS' named entity 'ARCHITECTURE' named entity 'COORDINATE' named entity 'REPLICATION' named entity 'VIRUSES' named entity 'BIOGENESIS' named entity 'ACTIVATION' named entity 'FORM' named entity 'NUCLEATED' named entity 'VIRAL PROTEINS' named entity 'INTRINSIC' named entity 'CELLS' named entity 'REOVIRUSES' named entity 'APPLICATIONS' named entity 'VIRUSES' named entity 'VIRAL RNA' named entity 'ASSEMBLY' named entity 'ADVANCE' named entity 'REOVIRUS' named entity 'ABOUT' named entity 'PROTEIN COMPLEXES' named entity 'CONCENTRATE' named entity 'OUR'

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