About: Diagnostic performance of two highly multiplexed respiratory virus assays in a pediatric cohort

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Diagnostic performance of two highly multiplexed respiratory virus assays in a pediatric cohort
Creator	Gaydos, Charlotte Advani, Sonali Newman, Christina Valsamakis, Alexandra Forman, Michael Milstone, Aaron
Source	Elsevier; Medline; PMC
abstract	Abstract Background Rapid detection of respiratory viruses is important for management and infection control in hospitalized patients. Multiplex nucleic acid tests (NATs) have begun to replace conventional methods as gold standards for respiratory virus detection. Objective To compare the performance of two large multiplex NATS, ResPlex II (RPII) and Respiratory Virus Surveillance kit with electrospray ionization mass spectrometry (RVS/MS) using nasopharyngeal aspirates (NPAs) from hospitalized children who had been tested previously with conventional methods. Study design Stored residual NPAs (N =306) were tested concomitantly by RPII and RVS/MS. Alternate NATs were used to adjudicate discordant results. Results More viruses were detected with multiplex NATs (RPII, 110; RVS/MS, 109) than conventional assays (86); diagnostic gain was primarily for fastidious viruses (coronaviruses and enteroviruses [EVs]/human rhinoviruses [HRVs]). Total positive and negative agreement between the multiplex NATs for all viruses detected was quite high (86% positive agreement, 99% negative agreement). Most individual viruses were detected with fairly equivalent accuracy by the multiplex NATs, except for adenoviruses (RPII sensitivity 40%) and human metapneumovirus (RVS/MS sensitivity 42%). RPII had the advantage of detecting EVs and HRVs, however, it demonstrated considerable EV/HRV cross-reactivity (29 HRV-positive specimens by real-time PCR were positive for EV by RPII and 21 specimens positive for HRV only by RT-PCR were dual positive for EV/HRV by RPII). RPII also had reduced sensitivity for HRV detection (in 36 specimens, HRV was detected by RT-PCR but not by RPII). Conclusions Both multiplex NATs were promising, but had notable limitations.
has issue date	2012-10-31(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2012.06.019
bibo:pmid	22832060
has license	els-covid
sha1sum (hex)	9be84e01a32ee5dbe44a6f2f93ee3b4933a495a3
schema:url	https://doi.org/10.1016/j.jcv.2012.06.019
resource representing a document's title	Diagnostic performance of two highly multiplexed respiratory virus assays in a pediatric cohort
has PubMed Central identifier	PMC3586269
has PubMed identifier	22832060
schema:publication	Journal of Clinical Virology
resource representing a document's body	covid:9be84e01a32ee5dbe44a6f2f93ee3b4933a495a3#body_text
is schema:about of	named entity 'HIGHLY' named entity 'HIGH' named entity 'TO COMPARE' named entity 'EVS' named entity 'RHINOVIRUSES' named entity 'VIRUS DETECTION' named entity 'HOSPITALIZED PATIENTS' named entity 'ELECTROSPRAY IONIZATION MASS SPECTROMETRY ' named entity 'CONCLUSIONS' named entity 'OBJECTIVE' named entity 'RESULTS' named entity 'AGREEMENT' named entity 'USING' named entity 'DEMONSTRATED' named entity 'HRV' named entity 'ADENOVIRUSES' named entity 'CROSS' named entity 'POSITIVE AND NEGATIVE' named entity 'POSITIVE' named entity 'PERFORMANCE' named entity 'DETECTION' named entity 'REDUCED' named entity 'LIMITATIONS' named entity 'RT-PCR' named entity 'KIT' named entity 'RESPIRATORY VIRUSES' named entity 'ENTEROVIRUSES' named entity 'ADVANTAGE' named entity 'METHODS' named entity 'MULTIPLEX' named entity 'LARGE' named entity 'TESTS' named entity '110' named entity 'DETECTING' named entity 'STUDY DESIGN' named entity 'IMPORTANT' named entity '2886' named entity 'PEDIATRIC COHORT' named entity 'NEGATIVE' named entity 'HAVE' named entity 'GOLD STANDARDS' named entity 'RPII' named entity 'ALTERNATE' named entity 'MANAGEMENT' named entity 'INFECTION CONTROL' named entity 'HOSPITALIZED CHILDREN' named entity 'DETECTED' named entity 'SPECIMENS' named entity 'PREVIOUSLY' named entity 'STORED' named entity 'USED' named entity 'RVS' named entity 'BUT' named entity 'VIRUSES' named entity 'RESPIRATORY VIRUS' named entity 'DIAGNOSTIC' named entity 'NUCLEIC ACID' named entity 'CONVENTIONAL' named entity 'BACKGROUND' named entity 'DISCORDANT' named entity 'RAPID' named entity 'REPLACE' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'ASPIRATES' named entity 'REAL-TIME PCR ' named entity 'EXCEPT FOR' named entity 'REACTIVITY' named entity 'RESIDUAL' named entity 'ACCURACY' named entity 'DUAL' named entity 'NOTABLE' named entity 'SENSITIVITY' named entity 'NASOPHARYNGEAL' named entity 'PERFORMANCE' named entity '40%' named entity 'GAIN'

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