About: Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model

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About: Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model
Creator	Alejandre-Aguilar, Ricardo Aranda-Fraustro, Alberto Arce-Fonseca, Minerva García-Mendoza, Humberto Rodríguez-Morales, Olivia Vallejo, Maite Ballinas-Verdugo, Martha Carrillo-Sánchez, Silvia Luis Rosales-Encina, José
source	Medline; PMC
abstract	The dog is considered the main domestic reservoir for Trypanosoma cruzi infection and a suitable experimental animal model to study the pathological changes during the course of Chagas disease (CD). Vaccine development is one of CD prevention methods to protect people at risk. Two plasmids containing genes encoding a trans-sialidase protein (TcSP) and an amastigote-specific glycoprotein (TcSSP4) were used as DNA vaccines in a canine model. Splenomegaly was not found in either of the recombinant plasmid-immunized groups; however, cardiomegaly was absent in animals immunized only with the plasmid containing the TcSSP4 gene. The inflammation of subendocardial and myocardial tissues was prevented only with the immunization with TcSSP4 gene. In conclusion, the vaccination with these genes has a partial protective effect on the enlargement of splenic and cardiac tissues during the chronic CD and on microscopic hearth damage, since both plasmids prevented splenomegaly but only one avoided cardiomegaly, and the lesions in heart tissue of dog immunized with plasmid containing the TcSSP4 gene covered only subepicardial tissue.
has issue date	2013-09-19(xsd:dateTime)
bibo:doi	10.1155/2013/826570
bibo:pmid	24163822
has license	cc-by
sha1sum (hex)	9c35a7f4d301162bfc79c1d7174a234ab94c2c46
schema:url	https://doi.org/10.1155/2013/826570
resource representing a document's title	Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model
has PubMed Central identifier	PMC3791577
has PubMed identifier	24163822
schema:publication	Biomed Res Int
resource representing a document's body	covid:9c35a7f4d301162bfc79c1d7174a234ab94c2c46#body_text
is schema:about of	named entity 'MODEL' named entity 'TRYPANOSOMA CRUZI INFECTION' named entity 'reservoir' named entity 'tissues' named entity 'plasmid' named entity 'protein' named entity 'Chronic' named entity 'Vaccination' named entity 'Canine' named entity 'COURSE' named entity 'RESERVOIR' named entity 'MICROSCOPIC' named entity 'CAUSED BY' named entity 'DAMAGE' named entity 'EFFECT' named entity 'MYOCARDIAL' named entity 'PEOPLE' covid:arg/9c35a7f4d301162bfc79c1d7174a234ab94c2c46 named entity 'USED' named entity 'NOT FOUND' named entity 'THESE' named entity 'TISSUES' named entity 'TRANS-SIALIDASE' named entity 'CANINE' named entity 'PLASMID' named entity 'CARDIAC' named entity 'RECOMBINANT PLASMID' named entity 'CARDIOMEGALY' named entity 'CONCLUSION' named entity 'EXPERIMENTAL ANIMAL MODEL' named entity 'EITHER' named entity 'ENLARGEMENT' named entity 'MACROSCOPIC' named entity 'PLASMID' named entity 'MAIN' named entity 'STUDY' named entity 'PATHOLOGICAL' named entity 'CANINE' named entity 'EXPERIMENTAL' named entity 'DOMESTIC' named entity 'IMMUNIZATION' named entity 'PLASMIDS' named entity 'AT RISK' named entity 'CHANGES' named entity 'PROTECTIVE EFFECT' named entity 'PROTEIN ' named entity 'ENCODING' named entity 'VACCINATION' named entity 'GENE' named entity 'IMMUNIZED' named entity 'ONE OF' named entity 'DNA VACCINES' named entity 'ANIMALS' named entity 'MODEL' named entity 'HEARTH' named entity 'GROUPS' named entity 'SUITABLE' named entity 'GENES' named entity 'DAMAGE' named entity 'CHRONIC' named entity 'TISSUE' named entity 'BUT' named entity 'SPLENOMEGALY' named entity 'HEART TISSUE' named entity 'ABSENT' named entity 'DOG' named entity 'SPECIFIC' named entity 'LESIONS' named entity 'DNA VACCINATION' named entity 'SPLENIC' named entity 'INFLAMMATION' named entity 'CONSIDERED' named entity 'AMASTIGOTE'

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