About: Activation of the Canonical Bone Morphogenetic Protein (BMP) Pathway during Lung Morphogenesis and Adult Lung Tissue Repair

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About: Activation of the Canonical Bone Morphogenetic Protein (BMP) Pathway during Lung Morphogenesis and Adult Lung Tissue Repair Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Activation of the Canonical Bone Morphogenetic Protein (BMP) Pathway during Lung Morphogenesis and Adult Lung Tissue Repair
Creator	Andreakos, Evangelos Apostolou, Eirini Chen, Huaiyong Giaglis, Stavros Monteiro, Rui Mummery, Christine Sideras, Paschalis Sountoulidis, Alexandros Stavropoulos, Athanasios Stripp, Barry Chuva De Sousa Lopes, Susana
topic	covid:9c39ab56559377e3b362be55e8e989e059a01fb0#this
Source	PMC
abstract	Signaling by Bone Morphogenetic Proteins (BMP) has been implicated in early lung development, adult lung homeostasis and tissue-injury repair. However, the precise mechanism of action and the spatio-temporal pattern of BMP-signaling during these processes remains inadequately described. To address this, we have utilized a transgenic line harboring a BMP-responsive eGFP-reporter allele (BRE-eGFP) to construct the first detailed spatiotemporal map of canonical BMP-pathway activation during lung development, homeostasis and adult-lung injury repair. We demonstrate that during the pseudoglandular stage, when branching morphogenesis progresses in the developing lung, canonical BMP-pathway is active mainly in the vascular network and the sub-epithelial smooth muscle layer of the proximal airways. Activation of the BMP-pathway becomes evident in epithelial compartments only after embryonic day (E) 14.5 primarily in cells negative for epithelial-lineage markers, located in the proximal portion of the airway-tree, clusters adjacent to neuro-epithelial-bodies (NEBs) and in a substantial portion of alveolar epithelial cells. The pathway becomes activated in isolated E12.5 mesenchyme-free distal epithelial buds cultured in Matrigel suggesting that absence of reporter activity in these regions stems from a dynamic cross-talk between endoderm and mesenchyme. Epithelial cells with activated BMP-pathway are enriched in progenitors capable of forming colonies in three-dimensional Matrigel cultures. As lung morphogenesis approaches completion, eGFP-expression declines and in adult lung its expression is barely detectable. However, upon tissue-injury, either with naphthalene or bleomycin, the canonical BMP-pathways is re-activated, in bronchial or alveolar epithelial cells respectively, in a manner reminiscent to early lung development and in tissue areas where reparatory progenitor cells reside. Our studies illustrate the dynamic activation of canonical BMP-pathway during lung development and adult lung tissue-repair and highlight its involvement in two important processes, namely, the early development of the pulmonary vasculature and the management of epithelial progenitor pools both during lung development and repair of adult lung tissue-injury.
has issue date	2012-08-20(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0041460
bibo:pmid	22916109
has license	cc-by
sha1sum (hex)	9c39ab56559377e3b362be55e8e989e059a01fb0
schema:url	https://doi.org/10.1371/journal.pone.0041460
resource representing a document's title	Activation of the Canonical Bone Morphogenetic Protein (BMP) Pathway during Lung Morphogenesis and Adult Lung Tissue Repair
has PubMed Central identifier	PMC3423416
has PubMed identifier	22916109
schema:publication	PLoS One
resource representing a document's body	covid:9c39ab56559377e3b362be55e8e989e059a01fb0#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/9c39ab56559377e3b362be55e8e989e059a01fb0
is schema:about of	named entity 'naphthalene' named entity 'remains' named entity 'Monteiro' named entity 'proximal' named entity 'Citation' named entity 'isolated' named entity 'dynamic' named entity 'tissue' named entity 'allele' named entity 'Lung' named entity 'Morphogenetic' named entity 'Lung' covid:arg/9c39ab56559377e3b362be55e8e989e059a01fb0 named entity 'illustrate' named entity 'early' named entity 'dynamic' named entity 'clusters' named entity 'buds' named entity 'However' named entity 'epithelial cells' named entity 'adult' named entity 'Lung' named entity 'processes' named entity 'epithelial cells' named entity 'progenitor cells' named entity 'airways' named entity 'active' named entity 'developing' named entity 'Adult' named entity 'homeostasis' named entity 'barely' named entity 'Protein' named entity 'lung' named entity 'activation' named entity 'canonical' named entity 'three-dimensional' named entity 'lung development' named entity 'Canonical' named entity 'Epithelial' named entity 'vasculature' named entity 'BMP' named entity 'epithelial' named entity 'lung tissue' named entity 'homeostasis' named entity 'Matrigel' named entity 'allele' named entity 'progenitor cells' named entity 'vascular network' named entity 'lung tissue' named entity 'BMP' named entity 'Epithelial cells' named entity 'BMP' named entity 'lung' named entity 'epithelial' named entity 'Lung' named entity 'Bone Morphogenetic Protein' named entity 'Lung Tissue' named entity 'distal' named entity 'areas' named entity 'ectopic expression' named entity 'Shh' named entity 'epithelial' named entity 'mice' named entity 'CD31' named entity 'BMP' named entity 'Bleomycin' named entity 'primers' named entity 'endoderm' named entity 'large blood vessels'

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