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About:
Human Parainfluenza Virus-Associated Respiratory Tract Infection among Children and Genetic Analysis of HPIV-3 Strains in Beijing, China
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schema:ScholarlyArticle
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Human Parainfluenza Virus-Associated Respiratory Tract Infection among Children and Genetic Analysis of HPIV-3 Strains in Beijing, China
Creator
Zhang, Yan
Liu, Chunyan
Shen, Kunling
Xie, Zhengde
An, Junjing
Ji, Yixin
Xu, Wenbo
Cui, Aili
Mao, Naiying
Zhu, Zhen
Yang, Weizhong
Wang, Huanhuan
Wang, Huiling
Xu, Songtao
Zhang, Xinxin
Source
Medline; PMC
abstract
The relevance of human parainfluenza viruses (HPIVs) to the epidemiology of acute respiratory infections (ARI) in China is unclear. From May 2008 to September 2010, 443 nasopharyngeal aspirates (NPAs) from hospitalized pediatric patients (age from 1 to 93 months) in Beijing were collected and screened for HPIVs and other common respiratory viruses by real-time RT-PCR. Sixty-two of 443 samples were positive for HPIVs with 4 positive for HPIV-2 and 58 positive for HPIV-3, indicating that HPIV-3 was the predominant virus present during the study period. A phylogenetic tree based on all the available HN (hemagglutinin-neuraminidase) sequences of HPIV-3 indicated that three distinct clusters (A,B, and C) were circulating with some temporal and regional clustering. Cluster C was further divided into sub-clusters, C1, C2, C3 and C4. HPIV-3 from Beijing isolates belonged to sub-cluster C3, and were grouped with the isolates from two Provinces of China and the neighboring country of Japan. Genetic analysis based on entire HN gene revealed that the HPIV-3 isolates from Beijing were highly similar with 97.2%–100% identity at the nucleotide level and these could be divided into two closely related lineages, C3a and C3b. These findings suggested that there was co-circulation of multiple lineages of HPIV-3 in the Beijing region during the study period. This is the first study to describe the epidemiology and molecular characterization of HPIVs in China.
has issue date
2012-08-28
(
xsd:dateTime
)
bibo:doi
10.1371/journal.pone.0043893
bibo:pmid
22937119
has license
cc-by
sha1sum (hex)
9ce08e8f877a798f4ff11d70112b69f92fc2427f
schema:url
https://doi.org/10.1371/journal.pone.0043893
resource representing a document's title
Human Parainfluenza Virus-Associated Respiratory Tract Infection among Children and Genetic Analysis of HPIV-3 Strains in Beijing, China
has PubMed Central identifier
PMC3429441
has PubMed identifier
22937119
schema:publication
PLoS One
resource representing a document's body
covid:9ce08e8f877a798f4ff11d70112b69f92fc2427f#body_text
is
schema:about
of
named entity 'ARI'
named entity 'human parainfluenza viruses'
named entity 'Beijing'
named entity 'ASSOCIATED'
named entity 'CHILDREN'
named entity 'RELEVANCE'
named entity 'CHINA'
named entity 'HUMAN PARAINFLUENZA VIRUSES'
named entity 'EPIDEMIOLOGY'
named entity 'CHINA'
named entity 'HUMAN PARAINFLUENZA VIRUS'
named entity 'RESPIRATORY TRACT INFECTION'
named entity 'GENETIC ANALYSIS'
named entity 'ACUTE RESPIRATORY INFECTIONS'
named entity 'BEIJING'
named entity 'HPIV-3'
named entity 'STRAINS'
named entity 'UNCLEAR'
named entity 'Genetic'
named entity 'China'
named entity 'HPIV-1'
named entity 'positive control'
named entity 'sequenced'
named entity 'HPIV'
named entity 'PCR'
named entity 'OC43'
named entity 'young children'
named entity 'anti-sense'
named entity 'HPIV'
named entity 'Saudi Arabia'
named entity 'nucleotide'
named entity 'respiratory tract infection'
named entity 'vaccination'
named entity 'HPIV-1'
named entity 'Beijing'
named entity 'coding region'
named entity 'Canada'
named entity 'infection'
named entity 'young children'
named entity 'HPIV-1'
named entity 'mainland China'
named entity 'virus'
named entity 'glycoprotein'
named entity 'primer'
named entity 'amino acid sequences'
named entity 'hemagglutinin'
named entity 'viruses'
named entity 'HPIV'
named entity 'infection'
named entity '6-carboxyfluorescein'
named entity 'PCR'
named entity 'reverse transcription polymerase chain reaction'
named entity 'cough'
named entity 'reverse transcription'
named entity 'HMPV'
named entity 'biological functions'
named entity 'viruses'
named entity 'HPIV'
named entity 'diagnostic assays'
named entity 'frame-shift'
named entity 'proof reading'
named entity 'viruses'
named entity 'PCR'
named entity 'genetic diversity'
named entity 'phylogenetic analyses'
named entity 'Tom Hall'
named entity 'China'
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