About: Anti-oxidant and Anti-Inflammatory Cyclic Diarylheptanoids from Alnus japonica Stem Bark

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About: Anti-oxidant and Anti-Inflammatory Cyclic Diarylheptanoids from Alnus japonica Stem Bark Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Anti-oxidant and Anti-Inflammatory Cyclic Diarylheptanoids from Alnus japonica Stem Bark
Creator	Mohamed, Gamal Aljaeid, Bader Ibrahim, Sabrin Khedr, I Madinah, Al Munawarah, Al
source	Medline; PMC
abstract	A new cyclic diarylheptanoid namely alnuheptanoid B (3), along with four known cyclic diarylheptanoids: myricanone (1), (+)-S-myricanol (2), myricanone 5-O- -D-glucopyranoside (4), and (+)-S-myricanol 5-O- -D-glucopyranoside (5) were isolated from the EtOAc fraction of Alnus japonica Steud (family: Betulaceae) stem bark. Their structures were established by different spectroscopic analyses, as well as optical rotation measurement. Compounds 1, 2, 4, and 5 are isolated for the first time from A. japonica. The antioxidant and anti-inflammatory activities of compounds (1-5) were assessed using DPPH assay and carrageenin induced rat paw edema model, respectively. They displayed significant antioxidant activity in relation to propyl gallate (standard antioxidant) at concentration 50 µM. Compound 2 demonstrated anti-inflammatory effect at a dose 10 mg/kg compared with indomethacin (positive control).
has issue date	2017-01-01(xsd:dateTime)
bibo:pmid	29844779
has license	cc-by
sha1sum (hex)	9e115f050e9a4bfa777fcbf79204014270383274
resource representing a document's title	Anti-oxidant and Anti-Inflammatory Cyclic Diarylheptanoids from Alnus japonica Stem Bark
has PubMed Central identifier	PMC5963649
has PubMed identifier	29844779
schema:publication	Iran J Pharm Res
resource representing a document's body	covid:9e115f050e9a4bfa777fcbf79204014270383274#body_text
is schema:about of	named entity 'KNOWN' named entity 'THEIR' named entity 'OPTICAL ROTATION MEASUREMENT' named entity 'STRUCTURES' named entity 'PROPYL GALLATE' named entity 'USING' named entity 'CONTROL' named entity 'ANTIINFLAMMATORY EFFECT' named entity 'CYCLIC' named entity 'FRACTION OF' named entity 'EDEMA' named entity 'OXIDANT' named entity 'STEM BARK' named entity 'model' named entity 'ALNUS JAPONICA' named entity 'DIARYLHEPTANOIDS' named entity 'COMPOUND' named entity 'ETOAC' named entity 'MODEL' named entity 'CARRAGEENIN' named entity 'MYRICANONE' named entity 'INDOMETHACIN' named entity 'DEMONSTRATED' named entity 'BETULACEAE' named entity 'STEM BARK' named entity 'RELATION' named entity 'ANTIOXIDANT' named entity 'MG%' named entity 'CYCLIC' covid:arg/9e115f050e9a4bfa777fcbf79204014270383274 named entity 'ANTI-INFLAMMATORY' named entity 'DISPLAYED' named entity 'ANTI-INFLAMMATORY' named entity 'JAPONICA' named entity 'ASSESSED' named entity 'TIME' named entity 'DIARYLHEPTANOIDS' named entity '283' named entity 'RAT' named entity 'CONCENTRATION' named entity 'ANTIOXIDANT ACTIVITY' named entity 'ALNUS JAPONICA' named entity 'ACTIVITIES' named entity 'DPPH ASSAY' named entity 'SIGNIFICANT' named entity 'DIFFERENT' named entity 'DIARYLHEPTANOID' named entity 'MYRICANOL' named entity 'NEW' named entity 'PAW' named entity 'INDUCED' named entity 'COMPARED' named entity 'ESTABLISHED' named entity 'ISOLATED' named entity 'DOSE' named entity '282' named entity 'relation' named entity 'activity' named entity 'DPPH' named entity 'cyclic' named entity 'diarylheptanoids' named entity 'Compound' named entity 'positive control' named entity 'antiinflammatory' named entity 'rat' named entity 'EtOAc' named entity 'diarylheptanoid' named entity 'anti-inflammatory' named entity 'Betulaceae' named entity 'antioxidant' named entity 'Alnus japonica' named entity 'Anti-Inflammatory' named entity 'indomethacin' named entity 'MeOH' named entity 'hydroxyl' named entity 'carrageenin' named entity 'H-8' named entity 'molecular ion'

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